A research team headed by Dr. Scott Bultman (University of North Carolina) has identified an essential role for the mammalian SWI/SNF chromatin remodeling complex in red blood cell formation. The authors generated a partial loss-of-function mutations in the ATPase domain of the SWI/SNF catalytic subunit, Brg1, effectively uncoupling its ATPase and chromatin remodeling activities.
Brg1-mutant mice die at mid-gestation due to defective erythropoiesis. Commenting on the relevance to human disease, the authors pointed out that "although much is known about the biochemistry of SWI/SNF chromatin-remodeling complexes, not as much is known about their role in development and physiology.
This Brg1 mutation is significant because it reveals a role for these complexes in beta-globin regulation and erythropoiesis and may provide insight into common ailments such as beta thalassemia and anemia."
Heather Cosel | EurekAlert!
New findings help to better calculate the oceans’ contribution to climate regulation
14.11.2018 | Jacobs University Bremen gGmbH
How algae and carbon fibers could sustainably reduce the athmospheric carbon dioxide concentration
14.11.2018 | Technische Universität München
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
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14.11.2018 | Life Sciences