Critical connections that neurons form in the brain during development turn out to rely on common but overlooked cells, called glia. These cells were known to support the neurons in adults, but had never been fingered as players in forming the connections between neurons, known as synapses.
The Stanford University School of Medicine researchers who conducted the work, led by Ben Barres, MD, PhD, professor of neurobiology, also discovered two of the proteins made by glial cells that signal synapse formation. This study, published in the Feb. 11 issue of Cell, could help researchers understand diseases such as epilepsy and addiction in which too many synapses form.
"We knew glia had a close relationship with neurons," Barres said. "We never thought the synapses would entirely fail to form without the glia." In fact, that relationship was considered so unlikely that the grant application was turned down six times because the work was considered too risky. The research was eventually funded by the National Institute on Drug Abuse, whose interest in the work stems from the possibility that new synapses are what keep recovered addicts craving drugs.
Amy Adams | EurekAlert!
New findings help to better calculate the oceans’ contribution to climate regulation
14.11.2018 | Jacobs University Bremen gGmbH
How algae and carbon fibers could sustainably reduce the athmospheric carbon dioxide concentration
14.11.2018 | Technische Universität München
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
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On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
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Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
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