Investigators from an international consortium of research institutes, including the Johns Hopkins Bloomberg School of Public Health, have identified compounds that mimic the effects of a low calorie diet without changing the amount of essential nutrients. The researchers believe it may be possible to design drugs that imitate many of the beneficial effects of calorie restriction resulting in the prevention of diseases, such as diabetes, heart disease and cancer, which are more common in people who are overweight. Their findings are published in the current online issue of the Journal of Biological Chemistry.
Co-author Thomas W. Kensler, PhD, a professor of Environmental Health Sciences at the Johns Hopkins Bloomberg School of Public Health, explained that calorie restriction has intrigued scientists for decades because it increases the life span of almost every species studied. In mammals, calorie restriction suppresses many diseases associated with the obesity epidemic. However, the mechanisms by which calorie restriction suppresses these diseases are not known.
Lead author, J. Christopher Corton, PhD, with ToxicoGenomics in Chapel Hill, N.C., examined the genetic changes that occur during calorie restriction in mice that were fed a diet for one month containing about 35 percent fewer calories than a normal diet. He explained that these genetic changes, which are referred to as a transcript profile, can be used like a bar-code to distinguish a unique profile from other genetic changes that occur in the body. The researchers compared the profile of calorie restriction with the profiles produced by compounds known to have some properties similar to calorie restriction, including the ability to suppress factors that lead to a number of diseases.
Kenna L. Lowe | EurekAlert!
Sensory Perception Is Not a One-Way Street
17.10.2018 | Eberhard Karls Universität Tübingen
Sex or food? Decision-making in single-cell organisms
17.10.2018 | Max-Planck-Institut für chemische Ökologie
Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
17.10.2018 | Event News
16.10.2018 | Event News
02.10.2018 | Event News
17.10.2018 | Trade Fair News
17.10.2018 | Life Sciences
17.10.2018 | Agricultural and Forestry Science