Researchers at the University of Virginia Health System have defined a molecular mechanism by which the activity of low-voltage-activated calcium channels can be decreased. Low-voltage-activated, T-type calcium channels are found in many types of tissue and alterations in their activity can contribute to several pathological conditions, including congestive heart failure, hypertension, cardiac arrhythmias, epilepsy and neuropathic pain. The findings will be published in the July 10 edition of Nature. The team led by Paula Q. Barrett, professor of pharmacology and principle investigator of the study, found that G-protein beta gamma subunits, a class of cell membrane proteins that mediate the actions of hormones within the cell, markedly decrease the flow of calcium through these channels into the cell interior. Because elevation of calcium within cells stimulates cellular activity, regulation of calcium entry is an important way by which the function of cells can be controlled. The research uncovered that only one member of a large family of G-protein subunits binds directly to the calcium channel protein to inhibit channel activity.
"These studies identify the T-type calcium channel as a new target for G-protein beta gamma subunits," Barrett said. "The extraordinary specificity of the interaction between these regulatory molecules could be operative in many types of cells and provides exciting insight into the highly selective ways in which cells work. Knowledge of these interactions will lead to the development of new and more specific drugs in the future."
Abena Foreman-Trice | EurekAlert!
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
19.07.2018 | Earth Sciences
19.07.2018 | Power and Electrical Engineering
19.07.2018 | Materials Sciences