Chronic lymphocytic leukemia (CLL)-the most common form of leukemia in adults-arises from a special type of white blood corpuscle, B lymphocytes, which normally produce antibodies to combat bacteria and viruses that we are exposed to. It is not known today what events lead to this disease.
A research team headed by Anders Rosén, professor of cell biology at Linköping University, has now established for the first time that the antibodies that CLL cells produce are highly specialized to recognize certain structures on the surface of bacteria and the body's own proteins (autoantigens).
The findings are being published on Monday in the respected hematological journal Blood. The key point is that the CLL antibodies also bind to damaged and dying (apoptotic) cells, which indicates that the B lymphocytes that give rise to CLL may be frontline defense cells. These are thought to have the extremely important task of using their antibodies to rapidly reveal the slightest breach in damaged mucous lining or skin, created by bacteria or other microorganisms.
But in long-term infections, these B lymphocytes can start to multiply excessively and rapidly. This increases the risk of chromosome damage, which in turn can cause them to turn into leukemia cells. The study now being published contributes to our understanding of how these B lymphocytes function and why they can be transformed into tumors.
CLL afflicts 400-500 people in Sweden each year, primarily among those aged 65-70 and more often among men than women. The disease has a highly varied course, with many patients living for decades with hardly any treatment, while others die within a few years despite treatment.
The research team behind the study also includes the doctoral students Eva Hellqvist and Anna Lanemo-Myrhinder, Linköping University, and Sohvi Hörkkö, Oulu, Finland, and Richard Rosenquist, Uppsala, Sweden.
The article, "A new perspective: molecular motifs on oxidized-LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies" is being published in Blood's First Edition Papers.
Contact: Anders Rosén, phone: +46 (0)13-222794; cell phone: +46 (0)707-303460, firstname.lastname@example.org
Pressofficer Åke Hjelm; email@example.com; +46-13 281 395
Åke Hjelm | idw
Platinum nanoparticles for selective treatment of liver cancer cells
15.02.2019 | ETH Zurich
New molecular blueprint advances our understanding of photosynthesis
15.02.2019 | DOE/Lawrence Berkeley National Laboratory
For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.
The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...
Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...
Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light
When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...
The so-called Abelian sandpile model has been studied by scientists for more than 30 years to better understand a physical phenomenon called self-organized...
Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of cryo-force spectroscopy and computer simulations, they were able to show that DNA molecules behave like a chain of small coil springs. The researchers reported their findings in Nature Communications.
DNA is not only a popular research topic because it contains the blueprint for life – it can also be used to produce tiny components for technical applications.
11.02.2019 | Event News
30.01.2019 | Event News
16.01.2019 | Event News
15.02.2019 | Physics and Astronomy
15.02.2019 | Physics and Astronomy
15.02.2019 | Life Sciences