Chronic lymphocytic leukemia (CLL)-the most common form of leukemia in adults-arises from a special type of white blood corpuscle, B lymphocytes, which normally produce antibodies to combat bacteria and viruses that we are exposed to. It is not known today what events lead to this disease.
A research team headed by Anders Rosén, professor of cell biology at Linköping University, has now established for the first time that the antibodies that CLL cells produce are highly specialized to recognize certain structures on the surface of bacteria and the body's own proteins (autoantigens).
The findings are being published on Monday in the respected hematological journal Blood. The key point is that the CLL antibodies also bind to damaged and dying (apoptotic) cells, which indicates that the B lymphocytes that give rise to CLL may be frontline defense cells. These are thought to have the extremely important task of using their antibodies to rapidly reveal the slightest breach in damaged mucous lining or skin, created by bacteria or other microorganisms.
But in long-term infections, these B lymphocytes can start to multiply excessively and rapidly. This increases the risk of chromosome damage, which in turn can cause them to turn into leukemia cells. The study now being published contributes to our understanding of how these B lymphocytes function and why they can be transformed into tumors.
CLL afflicts 400-500 people in Sweden each year, primarily among those aged 65-70 and more often among men than women. The disease has a highly varied course, with many patients living for decades with hardly any treatment, while others die within a few years despite treatment.
The research team behind the study also includes the doctoral students Eva Hellqvist and Anna Lanemo-Myrhinder, Linköping University, and Sohvi Hörkkö, Oulu, Finland, and Richard Rosenquist, Uppsala, Sweden.
The article, "A new perspective: molecular motifs on oxidized-LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies" is being published in Blood's First Edition Papers.
Contact: Anders Rosén, phone: +46 (0)13-222794; cell phone: +46 (0)707-303460, firstname.lastname@example.org
Pressofficer Åke Hjelm; email@example.com; +46-13 281 395
Åke Hjelm | idw
A one-way street for salt
21.09.2018 | Julius-Maximilians-Universität Würzburg
Nerve cells in the human brain can “count”
21.09.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.
This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.
Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.
An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...
03.09.2018 | Event News
27.08.2018 | Event News
17.08.2018 | Event News
21.09.2018 | Trade Fair News
21.09.2018 | Earth Sciences
21.09.2018 | Health and Medicine