Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research at the University of Navarra discovers new compounds active against tuberculosis and malaria

24.01.2008
University of Navarra PhD in chemistry researcher, Esther Vicente, has discovered new compounds active for treating tuberculosis and malaria.

Her thesis, defended at the Faculty of Sciences in her home city of Pamplona, the capital of Navarre, describes the synthesis and characterisation of 65 derivatives of quinoxaline, the structure of which is similar to a number of antimalalarial and antituberculosis pharmaceutical drugs currently on the market. Of the molecules prepared, four stand out for their antimalalarial activity and 15 for their antituberculosis activity.

Ms Vicente’s work is within the framework of the line of research of the Medicines R+D Unit at this university, which studies new pharmaceutical drugs to combat forgotten diseases. It involves infectious pathologies that mainly affect developing countries and cause 35,000 deaths daily. Amongst these ailments are tuberculosis and malaria, being the infectious diseases in the world that kill most people – 3 million every year.

The synthesis and characterisation of the new compounds was undertaken at the Centro de Investigación de Farmacobiología Aplicada (CIFA) of the University of Navarra. Esther Vicente did research for five months at the London School of Hygiene and Tropical Medicine in the UK, where she drew up the evaluation of the antimalarial activity of her products. The antituberculosis work was carried out at the Southern Research Institute of Birmingham, within the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) that is subsidised by the National Institute of Allergy and Infectious Diseases in Bethesda (USA).

Studies continuing in London and the USA
Amongst the conclusions of this European PhD, the author emphasises the discovery of new molecules that are more active in vitro than chloroquine, the reference pharmaceutical drug for the treatment of malaria the causing parasite of which has developed resistances. Amongst these molecules four stand out – the most selective – and these continue to be studied in vivo at the London School of Hygiene and Tropical Medicine.

Also, the important in vitro antituberculosis work, under cytotoxicity and good selectivity of fifteen of these molecules, make them new leader compounds in the TAACF programme; thus, in-depth studies are being carried out on them at the University of Illinois and at the Colorado State University, both in the USA.

In her thesis Esther Vicente also describes a Computational Chemistry study which she drew up at the Instituto de Investigación en Fisicoquímica Teórica y Aplicada (INIFTA) in La Plata, Argentina. Here, using various computer programmes, she designed a theoretical model to estimate if a compound could be potentially active, a tool that could prove to be highly useful in the design of new structures active against forgotten diseases.

Irati Kortabitarte | EurekAlert!
Further information:
http://www.elhuyar.com

Further reports about: Malaria Navarra Tuberculosis antituberculosis compound

More articles from Life Sciences:

nachricht Cell Division at High Speed
19.06.2019 | Julius-Maximilians-Universität Würzburg

nachricht Monitoring biodiversity with sound: how machines can enrich our knowledge
18.06.2019 | Georg-August-Universität Göttingen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Successfully Tested in Praxis: Bidirectional Sensor Technology Optimizes Laser Material Deposition

The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.

Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

Im Focus: Tube anemone has the largest animal mitochondrial genome ever sequenced

Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.

The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Innovative powder revolutionises 3D metal printing

19.06.2019 | Materials Sciences

'Alexa, monitor my heart': Researchers develop first contactless cardiac arrest AI system for smart speakers

19.06.2019 | Information Technology

Clean lungs thanks to laser process exhaustion

19.06.2019 | Machine Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>