Valio's Lactobacillus rhamnosus GG (LGG®) is the most frequently studied and used probiotic. Under the supervision of researchers at the Institute of Biotechnology, and the Department of Basic Veterinary Sciences at the University of Helsinki, an international research team determined the genome sequences of LGG and a bacterium closely related to it.
The results, published in the renowned PNAS journal, shed light on the origin of probiotic mechanisms and promote product development in the food industry.
Functional food includes products designed for daily use, which have been shown by clinical studies to have positive health effects. Scientific study results have particularly contributed to the success of dairy products containing probiotic bacteria. Many research publications have confirmed that these bacteria promote health and boosts immune system and improve digestion. Some probiotics can also alleviate the symptoms suffered by those with irritable bowel syndrome. As many as every fifth westerner suffers from this pain, also called spastic colon. Studies say that LGG probiotics are also an effective treatment method for reducing children's atopic symptoms, and the risk of respiratory infections.
In its recent publication, the research team showed that the protein component found by the team has a fundamental role in LGG binding with the human intestinal mucus. The team found out that the surface structures of LGG has a specific adhesion component. Remarkably, the binding feature has been assumed to be one of the most important characteristics of bacteria with health-benefiting effects. Moreover, the researchers assume that the protein structure in question enables the health-promoting effects of LGG and other probiotic bacteria, and the positive immune modulation produced by them.
The research is a prime example of productive co-operation between researchers and the food industry. According to Tuomas Salusjärvi, research manager for Valio, the successful sequencing provides valuable additional information to support the already existing research information. The safety of the LGG probiotic and its advantages to consumers can now be shown in an even better way than before. A significant research field has been established around probiotic bacteria. So far, thousands of scientific articles have been published on the subject. For this line of research, the findings of the genome, and the molecular mechanism possibly behind probiotics, is a downright breakthrough.
The original publication is available online at: http://www.pnas.org/content/early/2009/09/16/0908876106.abstract
The research has been funded by the Academy of Finland, and the Finnish Funding Agency for Technology and Innovation (TEKES).Additional information:
Matti Kankainen | EurekAlert!
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
Staying in Shape
16.08.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
17.08.2018 | Materials Sciences
17.08.2018 | Information Technology
17.08.2018 | Physics and Astronomy