A team of investigators from the University of Rochester Medical Center has developed a vaccine that can prevent bacterial infection of orthopaedic implants. Their findings were presented at the Orthopaedic Research Society (ORS) 2012 Annual Meeting in San Francisco, California.
The team, led by Edward Schwarz, PhD, Professor of Orthopaedics and Associate Director of the Center for Musculoskeletal Research, has generated an antibody that prevents MRSA bacteria from dividing properly.
"What makes the staph such a challenging pathogen is that is has an ironclad cell wall. But that is also its Achilles' heel," Dr. Schwarz said. He explained that if the cell wants to divide, it has to "unzip the cell wall" to break into two "daughter cells." Their team produced an antibody that targets a component of the zipper, Gmd—preventing normal bacterial cell division by causing them to form clusters of cells.
The researchers tested the antibody prior to implantation of a MRSA-infected pin to simulate an infected joint replacement. They monitored bacterial growth and found that their antibody protected 50 percent of their sample from infection. Further analysis found that the antibody prevented formation of sequestrum, or a piece of dead bone, which is a hallmark of osteomyelitis. Additionally, immunization led to decreased bacterial presence on the pins themselves.
Based on these findings, this immunization appears to be a promising treatment to prevent the MRSA infection/reinfection of orthopaedic implants.
Dr. Schwarz and his team were recently awarded a five-year multimillion dollar grant from AOTrauma, a not for profit Swiss foundation, for the Clinical Priority Program grant on infection. This grant deals with the diagnosis, treatment, prevention, and education about musculoskeletal infection.
About the Orthopaedic Research Society (ORS):
The Orthopaedic Research Society (ORS) is the pre-eminent organization for the advancement of musculoskeletal research. It seeks to transform the future through global multidisciplinary collaborations—focusing on the complex challenges of orthopaedic treatment. The ORS advances the global orthopaedic research agenda through excellence in research, education, collaboration, communication and advocacy. The ORS Annual Meeting and publication of the Journal of Orthopaedic Research provide vital forums for the musculoskeletal community to communicate the current state of orthopaedic research.
Annie Hayashi | EurekAlert!
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology