Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gut microbes battle a common set of viruses shared by global populations

25.06.2012
The human gut is home to a teeming ecosystem of microbes that is intimately involved in both human health and disease.

But while the gut microbiota is interacting with our body, they are also under constant attack from viruses. In a study published online in Genome Research, researchers have analyzed a bacterial immune system, revealing a common set of viruses associated with gut microbiota in global populations.

Viruses that prey on bacteria, called phages, pose a constant threat to the health of bacterial communities. In many ecological systems, viruses outnumber bacterial cells ten to one. Given the richness of bacteria in the human gut, it was not surprising that scientists have found that phages are also highly prevalent. But how can viruses targeting gut microbiota be identified? How do viral communities differ between people and global populations, and what could this tell us about human health and disease?

In this report, a team of scientists from Israel has taken advantage of information coded in a bacterial immune system to shed new light on these questions. Bacteria can "steal" small pieces of DNA from phages that attack them, and use these stolen pieces to recognize and respond to the attacker, in a manner similar to usage of antibodies by the human immune system. The stolen DNA pieces are stored in specific places in the bacterial genome called CRISPR loci (clustered regularly interspaced short palindromic repeats).

"In our study we searched for such stolen phage DNA pieces carried by bacteria living in the human gut," said Rotem Sorek of the Weizmann Institute of Science and senior author of the study. "We then used these pieces to identify DNA of phages that co-exist with the bacteria in the gut."

Sorek's team used this strategy to identify and analyze phages present in the gut microbiota of a cohort of European individuals. They found that nearly 80% of the phages are shared between two or more individuals. The team compared their data to samples previously derived from American and Japanese individuals, finding phages from their European data set also present in these geographically distant populations, a surprising result given the diversity of phages seen in other ecological niches.

Sorek explained that their findings mean that there are hundreds of types of viruses that repeatedly infect our gut microbiota. "These viruses can kill some of our gut bacteria," said Sorek. "It is therefore likely that these viruses can influence human health."

The authors note that as evidence for the beneficial roles played by bacteria in the healthy human gut continues to mount, it is critical that we understand the pressures placed upon the "good" bacteria that are vital to human health. "Our discovery of a large set of phages attacking these good bacteria in our gut opens a window for understanding how they affect human health," Sorek added. Researchers can now begin to ask how phage dynamics in the gut changes over time, and what it might tell us about diseases, such as inflammatory bowel disease, and how to more effectively treat them.

Scientists from the Weizmann Institute of Science (Rehovot, Israel) and Tel Aviv University (Tel Aviv, Israel) contributed to this study.

This work was supported by the ERC-StG Program, the Leona M. and Harry B. Helmsley Charitable Trust, the Deutsche Forschungsgemeinschaft, the AXA Research Fund, the Edmond J. Safra Bioinformatics Program at Tel Aviv University, and the Clore Center at the Weizmann Institute of Science.

Media contacts: The authors are available for more information by contacting Yivsam Azgad, Institute Spokesman and Head of Publications & Media Relations at the Weizmann Institute of Science (yivsam.azgad@weizmann.ac.il, + 972 8 934 3856).

Interested reporters may obtain copies of the manuscript via email from Peggy Calicchia, Administrative Assistant, Genome Research (calicchi@cshl.edu, +1-516-422-4012).

About the article: The manuscript will be published online ahead of print on June 25, 2012. Its full citation is as follows: Stern A, Mick E, Tirosh I, Sagy O, Sorek R. CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome. Genome Res doi: 10.1101/gr.138297.112.

About Genome Research:

Launched in 1995, Genome Research is an international, continuously published, peer-reviewed journal that focuses on research that provides novel insights into the genome biology of all organisms, including advances in genomic medicine. Among the topics considered by the journal are genome structure and function, comparative genomics, molecular evolution, genome-scale quantitative and population genetics, proteomics, epigenomics, and systems biology. The journal also features exciting gene discoveries and reports of cutting-edge computational biology and high-throughput methodologies.

About Cold Spring Harbor Laboratory Press:

Cold Spring Harbor Laboratory is a private, nonprofit institution in New York that conducts research in cancer and other life sciences and has a variety of educational programs. Its Press, originating in 1933, is the largest of the Laboratory's five education divisions and is a publisher of books, journals, and electronic media for scientists, students, and the general public.

Genome Research issues press releases to highlight significant research studies that are published in the journal.

Peggy Calicchia | EurekAlert!
Further information:
http://www.cshl.edu

More articles from Life Sciences:

nachricht Selectively Reactivating Nerve Cells to Retrieve a Memory
01.06.2020 | Universität Heidelberg

nachricht CeMM study reveals how a master regulator of gene transcription operates
01.06.2020 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Biotechnology: Triggered by light, a novel way to switch on an enzyme

In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".

Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

Im Focus: I-call - When microimplants communicate with each other / Innovation driver digitization - "Smart Health“

Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.

When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...

Im Focus: When predictions of theoretical chemists become reality

Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.

Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...

Im Focus: Rolling into the deep

Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

Black nitrogen: Bayreuth researchers discover new high-pressure material and solve a puzzle of the periodic table

29.05.2020 | Materials Sciences

Argonne researchers create active material out of microscopic spinning particles

29.05.2020 | Materials Sciences

Smart windows that self-illuminate on rainy days

29.05.2020 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>