Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Developing Chikungunya Virus Vaccines – Learning from the Immune Response towards the Infection

18.12.2019

Researchers at the Paul-Ehrlich-Institut (PEI), Federal Institute for Vaccines and Biomedicines have been working in an international research partnership to investigate the immune response to the Chikungunya virus (CHIKV), which is mediated by antibody formation. Antibody levels in humans were higher after successfully surviving CHIKV infection than after vaccination with a candidate vaccine against Chikungunya. The Journal of Infectious Diseases reports on the results in its online version of 12.12.2019.

The Chikungunya virus (CHIKV) is transmitted by aedes mosquitos such as the Asian tiger mosquito (Aedes albopictus) and causes Chikungunya fever in humans.


The Chikungunya virus (CHIKV) is transmitted by aedes mosquitos such as the Asian tiger mosquito (Aedes albopictus) and causes Chikungunya fever in humans.

(Source: https://www.pei.de/EN/newsroom/press-releases/year/2019/25-developing-chikungunya-virus-vaccines.html)

Scientists led by Prof. Barbara Schnierle, head of the "AIDS, New and Novel Pathogens" department, and Dr. Sally Baylis, researcher in the Virus Safety department of the Paul-Ehrlich-Institut, in collaboration with researchers from Themis Bioscience GmBH, Austria, and the Instituto Oswaldo Cruz, Rio de Janeiro, Brazil, have investigated the generation of CHIKV-specific antibodies in individuals who had suffered from a CHIKV infection and recovered.

This humoral immune response, i.e. the type and extent of antibody formation against the pathogen was compared with the formation of antibodies from healthy participants who had been vaccinated with a Chikungunya vaccine candidate. The vaccine candidate investigated in this study was a measles vector vaccine (MV-CHIK).

In the study, her team compared the type and extent of antibody formation with the formation of antibodies (humoral response) in healthy participants who had been vaccinated with a Chikungunya vaccine candidate (measles vector vaccine MV-CHIK). In those individuals who had undergone a CHIKV infection, CHIKV-specific antibody levels were two to six times higher than in vaccinated individual.

As the main antigen structures against which the antibodies were formed, the research group identified a binding domain of the envelope protein E2 as well as so-called acid sensitive regions (ASPs) of the virus for both groups. Some of the antibodies raised against these regions, known as neutralising antibodies, were able to prevent the CHIKV from entering the host cell.

“The findings are helpful for the design of effective vaccines, the evaluation of the efficacy, and the identification of specific neutralising antibodies to prevent the Chikungunya virus from entering into the target cells,” as Professor Schnierle explained the significance of these results.

Background

The CHIKV is predominant in tropical and subtropical regions and has already caused epidemics in Africa, parts of the Indian Ocean regions, South-East Asia, the Caribbean, as well as Central and South America. Chinkungunya infections are reported regularly from people returning home from travels. The infection is notifiable in Germany.

Since the Asian tiger mosquito is increasingly spreading and meanwhile also occurs in Germany, further spreading of the virus must be expected. Symptoms of a Chikungunya infection include fever and strong limb pain – a symptom from which the disease derives its name – Chikungunya means “the one who walks bent”. In 30 to 40 percent of the cases, this limb pain can last several months or even years. A vaccine is so far not available.

CHIKV is a single-strain RNA virus. Its envelope proteins E1 and E2 form docking sites on the surface of the virus, thus facilitating the infection in the host cell. CHIKV-specific antibodies are of major significance for the protection from the disease. Thus, mice were protected from a CHIKV infection after injection of CHIKV-specific monoclonal antibodies.

Originalpublikation:

Henss L, Yue C, von Rhein C, Tschismarov R, Lewis-Ximenez LL, Dölle A, Baylis SA, Schnierle BS (2019)
Analysis of humoral immune responses in chikungunya virus (CHIKV) infected patients and individuals vaccinated with a candidate CHIKV vaccine.
J Infect Dec 12 [Epub ahead of print].
DOI:10.1093/infdis/jiz658

Weitere Informationen:

https://doi.org/10.1093/infdis/jiz658 - Abstract of the publication

https://www.pei.de/EN/newsroom/press-releases/year/2019/25-developing-chikunguny... - this press release on the PEI website

Dr. Susanne Stöcker | Paul-Ehrlich-Institut - Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel

More articles from Life Sciences:

nachricht New self-assembled monolayer is resistant to air
22.01.2020 | University of Groningen

nachricht Mosquitoes are drawn to flowers as much as people -- and now scientists know why
22.01.2020 | University of Washington

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New roles found for Huntington's disease protein

Crucial role in synapse formation could be new avenue toward treatment

A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative...

Im Focus: A new look at 'strange metals'

For years, a new synthesis method has been developed at TU Wien (Vienna) to unlock the secrets of "strange metals". Now a breakthrough has been achieved. The results have been published in "Science".

Superconductors allow electrical current to flow without any resistance - but only below a certain critical temperature. Many materials have to be cooled down...

Im Focus: Programmable nests for cells

KIT researchers develop novel composites of DNA, silica particles, and carbon nanotubes -- Properties can be tailored to various applications

Using DNA, smallest silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) developed novel programmable materials....

Im Focus: Miniature double glazing: Material developed which is heat-insulating and heat-conducting at the same time

Styrofoam or copper - both materials have very different properties with regard to their ability to conduct heat. Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz and the University of Bayreuth have now jointly developed and characterized a novel, extremely thin and transparent material that has different thermal conduction properties depending on the direction. While it can conduct heat extremely well in one direction, it shows good thermal insulation in the other direction.

Thermal insulation and thermal conduction play a crucial role in our everyday lives - from computer processors, where it is important to dissipate heat as...

Im Focus: Fraunhofer IAF establishes an application laboratory for quantum sensors

In order to advance the transfer of research developments from the field of quantum sensor technology into industrial applications, an application laboratory is being established at Fraunhofer IAF. This will enable interested companies and especially regional SMEs and start-ups to evaluate the innovation potential of quantum sensors for their specific requirements. Both the state of Baden-Württemberg and the Fraunhofer-Gesellschaft are supporting the four-year project with one million euros each.

The application laboratory is being set up as part of the Fraunhofer lighthouse project »QMag«, short for quantum magnetometry. In this project, researchers...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

„Advanced Battery Power“- Conference, Contributions are welcome!

07.01.2020 | Event News

 
Latest News

New self-assembled monolayer is resistant to air

22.01.2020 | Life Sciences

Ultrafast camera takes 1 trillion frames per second of transparent objects and phenomena

22.01.2020 | Power and Electrical Engineering

Mosquitoes are drawn to flowers as much as people -- and now scientists know why

22.01.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>