Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Climbing Frames for Cells Influence Growth and Morphology

12.11.2014

Biophysical Research for Future Implants

With society growing older, implants are often necessary to preserve mobility and health-related quality of life. However, by far not all implantations are successful, and often lengthy and risky after-treatments are necessary, for example because the implant is not well integrated into bone.


PhD student Judith Hohmann, photo: Th. Jung

In order to make implants more reliable, their surface is roughened, so that the cells of the surrounding bone tissue grow faster into the surface. The cellular mechanisms of this growth enhancement are not yet known.

In a recently published study Professor Georg von Freymann and his PhD student Judith Hohmann, for the first time systematically showed the connections between three-dimensional surface structure and cell growth.

"If we understand how cells behave on differently structured surfaces, this could eventually lead to improved implants," the young biophysicist Hohmann explains the motivation for the research project. The work was carried out at the Physics Department of the University of Kaiserslautern within the framework of the State Research Center OPTIMAS.

To better understand the interaction of the cells, various structures were fabricated with feature sizes of a few microns. For this, Hohmann made use of 3D micro-printing that builds three-dimensional polymer structures from a liquid starting material.

The structures were then coated with titanium dioxide so that they are chemically identical to the surfaces of implants. On these structures, the young scientist let then cells grow that are very similar to those of bone tissue. Cell growth was then compared to that on unstructured surfaces.

The structures resembled micro climbing frames and were also used as such by the cells. Along the scaffolds the cells grew much faster than in the control experiments without structured surfaces for adhesion contact.

The cells had a distinct preference for certain shapes and distances of different scaffolds: A change in the spacing of posts of the climbing frame-like structures had significant influence on the growth of cells. Also the cell morphology strongly depends on their structural environment. The studies provided a first approach to better understand the growth behavior of the cells on the artificial material. Fortunately, the functionality of the cells was not affected, they still behave like bone tissue.

The results of this study may in future lead to improved implants that are overgrown quicker by the surrounding bone tissue. Von Freymann and Hohmann published their results in the internationally renowned journal Advanced Functional Materials. The editor of the journal even selected their study for the cover of the print edition.

For further information:
Influence of Direct Laser Written 3D Topographies on Proliferation and Differentiation of Osteoblast-Like Cells: Towards Improved Implant Surfaces
Judith K. Hohmann and Georg von Freymann
Advanced Functional Materials 24, 6573–6580 (2014); DOI: 10.1002/adfm.201401390

Contact:
Prof. Dr. Georg von Freymann, TU Kaiserslautern
(Phone +49 631 205 5225; georg.freymann@physik.uni-kl.de)


Weitere Informationen:

http://www.uni-kl.de

Thomas Jung | Technische Universität Kaiserslautern

More articles from Life Sciences:

nachricht Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides
16.07.2018 | Tokyo Institute of Technology

nachricht The secret sulfate code that lets the bad Tau in
16.07.2018 | American Society for Biochemistry and Molecular Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Subaru Telescope helps pinpoint origin of ultra-high energy neutrino

16.07.2018 | Physics and Astronomy

Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides

16.07.2018 | Life Sciences

New research calculates capacity of North American forests to sequester carbon

16.07.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>