Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antioxidants developed by MSU scientists slow down senescence in plants

11.06.2018

Ageing is a complex process involving lots of different mechanisms. One of the main processes on which ageing is based is the formation of reactive oxygen species (ROS). ROS are molecules formed as a result of a sequential one-electron reduction of oxygen. They are extremely chemically active and oxidize many compounds inside the cells. This leads to malfunctions in cellular molecular mechanisms and eventually to cell death.

ROS are frequently formed in mitochondria - the power factories of the cells. Mitochondria-targeted antioxidants, including SkQ ions, affect mitochondria directly and prevent the synthesis of dangerous molecules.


1 - Chloroplasts (fluorescence of chlorophyll),

2 - mitochondria stained with rhodamine dye,

3 - ROS (fluorescence of 2',7'-dichlorofluorescein),

4 - joint image of chloroplasts, mitochondria and ROS.

Credit: Courtesy of Dmitry Kiselevsky

Their action mechanism is not completely clear yet, but scientists believe it consists of two parts. The first one is a chemical reaction of SkQ with ROS or their products. The second is implemented due to the reduction of transmembrane difference of electric potentials in mitochondria which suppresses the formation of mitochondrial ROS.

A team from the department of immunology (Faculty of Biology, MSU) tested the effect of SkQ mitochondria-targeted antioxidants on plant cells. The main target of the study was to find out the influence of these substances on chloroplasts in which photosynthesis takes place.

The scientists demonstrated that in nanomolar concentrations SkQ suppressed the death of plant cells caused by the influence of poisons in pea leaves. In micromolar concentrations the antioxidants slowed down photosynthesis in chloroplasts and stimulated respiration in mitochondria.

The team also found out that SkQ antioxidants slowed down the senescence and death in the leaves of Arabidopsis thaliana, a plant from the Cruciferae family.

"An important moment for us was that these antioxidants contain plastoquinone from plants, namely from chloroplasts that capture and convert the energy of light into a form that is accessible to plants. Therefore we needed to study how these compounds would influence plant cells and interact with chloroplasts," - explained Dmitry Kiselevsky, a co-author of the study and a senior researcher of the Faculty of Biology, MSU.

The scientists also concluded that mitochondria-targeted antioxidants in low concentrations do not influence cell respiration and photosynthesis in chloroplasts. The antioxidants in question may be used in biotechnologies and agriculture in certain concentrations that do not affect these processes.

"The research of mitochondria-targeted antioxidants studies the role of mitochondria in the formation of ROS, as well as the programmed plant cell death. Currently our lab is working on the role of another energy exchange system (glycolysis) in the formation of ROS in plants," - added Dmitry Kiselevsky.

Media Contact

Yana Khlyustova
science-release@rector.msu.ru

http://www.msu.ru 

Yana Khlyustova | EurekAlert!
Further information:
http://dx.doi.org/10.1016/j.mito.2018.04.008

More articles from Life Sciences:

nachricht New study finds distinct microbes living next to corals
22.05.2019 | Woods Hole Oceanographic Institution

nachricht Summit charts a course to uncover the origins of genetic diseases
22.05.2019 | DOE/Oak Ridge National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Self-repairing batteries

UTokyo engineers develop a way to create high-capacity long-life batteries

Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...

Im Focus: Quantum Cloud Computing with Self-Check

With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.

Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...

Im Focus: Accelerating quantum technologies with materials processing at the atomic scale

'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.

However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...

Im Focus: A step towards probabilistic computing

Working group led by physicist Professor Ulrich Nowak at the University of Konstanz, in collaboration with a team of physicists from Johannes Gutenberg University Mainz, demonstrates how skyrmions can be used for the computer concepts of the future

When it comes to performing a calculation destined to arrive at an exact result, humans are hopelessly inferior to the computer. In other areas, humans are...

Im Focus: Recording embryonic development

Scientists develop a molecular recording tool that enables in vivo lineage tracing of embryonic cells

The beginning of new life starts with a fascinating process: A single cell gives rise to progenitor cells that eventually differentiate into the three germ...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Summit charts a course to uncover the origins of genetic diseases

22.05.2019 | Life Sciences

New study finds distinct microbes living next to corals

22.05.2019 | Life Sciences

Stellar waltz with dramatic ending

22.05.2019 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>