Ageing is a complex process involving lots of different mechanisms. One of the main processes on which ageing is based is the formation of reactive oxygen species (ROS). ROS are molecules formed as a result of a sequential one-electron reduction of oxygen. They are extremely chemically active and oxidize many compounds inside the cells. This leads to malfunctions in cellular molecular mechanisms and eventually to cell death.
ROS are frequently formed in mitochondria - the power factories of the cells. Mitochondria-targeted antioxidants, including SkQ ions, affect mitochondria directly and prevent the synthesis of dangerous molecules.
Their action mechanism is not completely clear yet, but scientists believe it consists of two parts. The first one is a chemical reaction of SkQ with ROS or their products. The second is implemented due to the reduction of transmembrane difference of electric potentials in mitochondria which suppresses the formation of mitochondrial ROS.
A team from the department of immunology (Faculty of Biology, MSU) tested the effect of SkQ mitochondria-targeted antioxidants on plant cells. The main target of the study was to find out the influence of these substances on chloroplasts in which photosynthesis takes place.
The scientists demonstrated that in nanomolar concentrations SkQ suppressed the death of plant cells caused by the influence of poisons in pea leaves. In micromolar concentrations the antioxidants slowed down photosynthesis in chloroplasts and stimulated respiration in mitochondria.
The team also found out that SkQ antioxidants slowed down the senescence and death in the leaves of Arabidopsis thaliana, a plant from the Cruciferae family.
"An important moment for us was that these antioxidants contain plastoquinone from plants, namely from chloroplasts that capture and convert the energy of light into a form that is accessible to plants. Therefore we needed to study how these compounds would influence plant cells and interact with chloroplasts," - explained Dmitry Kiselevsky, a co-author of the study and a senior researcher of the Faculty of Biology, MSU.
The scientists also concluded that mitochondria-targeted antioxidants in low concentrations do not influence cell respiration and photosynthesis in chloroplasts. The antioxidants in question may be used in biotechnologies and agriculture in certain concentrations that do not affect these processes.
"The research of mitochondria-targeted antioxidants studies the role of mitochondria in the formation of ROS, as well as the programmed plant cell death. Currently our lab is working on the role of another energy exchange system (glycolysis) in the formation of ROS in plants," - added Dmitry Kiselevsky.
Yana Khlyustova | EurekAlert!
Small but versatile; key players in the marine nitrogen cycle can utilize cyanate and urea
10.12.2018 | Max-Planck-Institut für Marine Mikrobiologie
Carnegie Mellon researchers probe hydrogen bonds using new technique
10.12.2018 | Carnegie Mellon University
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
10.12.2018 | Event News
06.12.2018 | Event News
03.12.2018 | Event News
10.12.2018 | Life Sciences
10.12.2018 | Physics and Astronomy
10.12.2018 | Life Sciences