Molecular scaffolding makes for good bone structure.
Programmed molecules build themselves into a bone-mimic.
Scientists in the United States have made self-assembling synthetic bone1. Carefully designed building-blocks join up to mimic bone’s complex molecular-scale architecture, bringing better prosthetics a step closer.
Materials engineers are keen to emulate the strength and toughness of biominerals such as bone, tooth and shell. Mollusc shells, for example, a composite of the mineral calcium carbonate and sheets of organic tissue, are much tougher than an equivalent slab of the mineral alone. So, like a biomineral, the bone-mimic is a blend of hard mineral-like substances and soft organic ones.
Sam Stupp and colleagues of Northwestern University in Illinois have tailor-made small protein-like molecules called peptides. To each peptide they attached a tail that was insoluble in water, encouraging them to assemble into cylindrical columns with their tails pointing inwards, shielded from water.
These long, flexible columns formed a tangle of worm-like fibres. Stupp’s team fixed the fibres in place by bonding adjacent peptides on their surfaces. Similar bonds link collagen fibres into the connective tissue between cells.
The team also included molecular groups such as those that promote hydroxyapatite crystal formation in natural proteins. Finally, they added groups that make proteins stick to cells. These, they reasoned, would allow the self-assembling web to harbour living cells.
The researchers put this matrix in a solution of ions - primarily calcium and phosphate. Hydroxyapatite crystals grew on the scaffold; their atomic layers aligned with the fibres, just as they do on the collagen scaffold of bone.
PHILIP BALL | © Nature News Service
Epoxy compound gets a graphene bump
14.11.2018 | Rice University
Automated adhesive film placement and stringer integration for aircraft manufacture
15.11.2018 | Fraunhofer IFAM
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences