Preventing overload in the brain

Brain researchers in Amsterdam have observed a double control system in the hippocampus. This double control system contributes to the memory and ensures that the brain does not `crash`, as is the case during an epileptic seizure.

The neurobiologists from the University of Amsterdam carried out their observations on the hippocampus of rats. The hippocampus probably plays an important role in converting the short-term memory to the long-term memory.

The hippocampus contains two sorts of brain cells: pyramidal cells and interneurons. Pyramidal cells are the most important cells in the hippocampus. They process incoming information and pass on information to pyramidal cells in other areas of the brain. The interneurons can control the activity of the pyramidal cells.

The researchers studied the electrical signals that nerve cells use to communicate. They found that the interneurons inhibit the pyramidal cells in two ways. Some interneurons receive the same signals as pyramidal cells and so they can control what information the pyramidal cells received. This is therefore a form of prior control. Other interneurons can only control the pyramidal cells when these want to issue new signals. They control the activity of the pyramidal cells retrospectively.

One advantage of the double control mechanism is that the brain can be continually alert without becoming overloaded. Epilepsy illustrates the importance of not being overloaded. During an epileptic seizure, the brain (including the hippocampus) becomes disorganised and all of the pyramidal cells fire signals at the same time. The brain becomes overloaded and can no longer respond adequately to external signals. The patient then becomes unconscious.

There are indications that the interneurons in epilepsy patients are affected, with the result that the pyramidal cells are less well controlled. Future research needs to establish which of the two types of interneurons is affected.

Media Contact

Michel Philippens alphjagalileo

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Pancreatic cancer’s cellular amnesia

Things aren’t always as they seem. Take pancreatic cancer, for example. In up to one in 10 cases, researchers have documented a peculiar characteristic. Some of the pancreatic cells appear…

Innovative Polymer Wound Dressings for Painless and Residue-Free Removal

A new approach enables dressings that adhere firmly to the skin at body temperature, but can be removed easily and painlessly in combination with a cold pack. The dressing adheres…

SETI Institute launches groundbreaking technosignature science and technology

Application deadline for grants is July 15, 2024. The SETI Institute is announcing the launch of a pioneering grants program dedicated to advancing technosignature science. This first-of-its-kind initiative aims to…

Partners & Sponsors