Glucosamine causes the death of pancreatic cells

In vitro tests conducted by Professor Frédéric Picard and his team revealed that glucosamine exposure causes a significant increase in mortality in insulin-producing pancreatic cells, a phenomenon tied to the development of diabetes. Cell death rate increases with glucosamine dose and exposure time.

“In our experiments, we used doses five to ten times higher than that recommended by most manufacturers, or 1,500 mg/day,” stressed Professor Picard. “Previous studies showed that a significant proportion of glucosamine users up the dose hoping to increase the effects,” he explained.

Picard and his team have shown that glucosamine triggers a mechanism intended to lower very high blood sugar levels. However, this reaction negatively affects SIRT1, a protein critical to cell survival. A high concentration of glucosamine diminishes the level of SIRT1, leading to cell death in the tissues where this protein is abundant, such as the pancreas.

Individuals who use large amounts of glucosamine, those who consume it for long periods, and those with little SIRT1 in their cells are therefore believed to be at greater risk of developing diabetes. In a number of mammal species, SIRT1 level diminishes with age. This phenomenon has not been shown in humans but if it were the case, the elderly—who constitute the target market for glucosamine—would be even more vulnerable.

“The key point of our work is that glucosamine can have effects that are far from harmless and should be used with great caution,” concluded Professor Picard.

The results obtained by Picard and his team coincide with recent studies that cast serious doubt on the effectiveness of glucosamine in treating joint problems.

This study was co-authored by Mathieu Lafontaine-Lacasse and Geneviève Doré.

Information:
Frédéric Picard
Faculty of Pharmacy
Université Laval
418-656-8711 ext. 3737
frederic.picard@criucpq.ulaval.ca

Media Contact

Jean-François Huppé EurekAlert!

More Information:

http://www.ulaval.ca

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Fast, cheap test can detect COVID-19 virus’ genome without need for PCR

Researchers at the University of Washington have developed a new test for COVID-19 that combines the speed of over-the-counter antigen tests with the accuracy of PCR tests that are processed…

Orbital insertion burn a success, Webb arrives at L2

24 Jan 2022, at 2 p.m. EST, Webb fired its onboard thrusters for nearly five minutes (297 seconds) to complete the final postlaunch course correction to Webb’s trajectory. This mid-course correction…

New, better coronavirus rapid test

Researchers at the Paul Scherrer Institute PSI and the University of Basel have developed a rapid test for Covid-19. Its novel functional principle promises reliable and quantifiable results concerning a…

Partners & Sponsors