Therapy of brain tumors by inhibition of nuclear receptor tailles (Tlx)
DKFZ researchers identified nuclear receptor tailles (Tlx) as a valuable drug target for brain tumors especially gliobastomas. In vivo experiments showed almost doubling in survival time of mice harbouring brain tumors by inhibiting the expression of Tlx in tumor cells. In addition a highly significant correlation between expression of Tlx in brain tumor cells and survival of the patient was demonstrated.
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DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
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Dr. Ruth Herzog
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