A receptor-dead mutein of bone morphogenetic protein 2 (BMP-2)
A new receptor-dead BMP-2 mutein L51P has been created that has no detectable BMP activity. Surprisingly, the BMP-2 L51P mutein exhibits an unaltered binding affinity for BMP modulator proteins of the Noggin, Chordin and DAN families. In cell culture experiments the mutein has been demonstrated to efficiently neutralize Noggin activity.
Further Information: PDF
Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V.
Phone: +49 (0)89/1205-6000
Contact
Dr. Wolfgang Knappe
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Trotting robots reveal emergence of animal gait transitions
A four-legged robot trained with machine learning by EPFL researchers has learned to avoid falls by spontaneously switching between walking, trotting, and pronking – a milestone for roboticists as well…
Innovation promises to prevent power pole-top fires
Engineers in Australia have found a new way to make power-pole insulators resistant to fire and electrical sparking, promising to prevent dangerous pole-top fires and reduce blackouts. Pole-top fires pose…
Possible alternative to antibiotics produced by bacteria
Antibacterial substance from staphylococci discovered with new mechanism of action against natural competitors. Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers…