Synthetic K receptor agonist for pain therapy – Novel class of k selective opioids for peripheral pain treatment
Natural and synthetic opioids are effective and widely
used drugs for the treatment of acute, post-operative or malignant pain. These drugs interact predominantly with μ-opioid receptors in the central nervous system. While being strong analgesics, these drugs also cause severe side effects due to their interaction with μ-opioid receptors in the brain. This limits the use of currently available opioids for palliative care. Not many drugs are available for the treatment of severe peripheral, chronic, neuropathic or non-malignant pain. However, k-opioid receptor agonists with high k receptor affinity and selectivity, which cannot pass the blood brain barrier, are suitable for this purpose. At the University of Münster, a new class of compounds with high k receptor affinity and selectivity as well as strong analgesic effects has been developed.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 0
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Sea slugs inspire highly stretchable biomedical sensor
USC Viterbi School of Engineering researcher Hangbo Zhao presents findings on highly stretchable and customizable microneedles for application in fields including neuroscience, tissue engineering, and wearable bioelectronics. The revolution in…
Twisting and binding matter waves with photons in a cavity
Precisely measuring the energy states of individual atoms has been a historical challenge for physicists due to atomic recoil. When an atom interacts with a photon, the atom “recoils” in…
Nanotubes, nanoparticles, and antibodies detect tiny amounts of fentanyl
New sensor is six orders of magnitude more sensitive than the next best thing. A research team at Pitt led by Alexander Star, a chemistry professor in the Kenneth P. Dietrich…
