Regio- and stereo-selective hydroxylation of terpenes
A new enzyme of the family of cytochrome p450 was found which is able to stereo-selective hydoxylate terpenes at the 15beta-position. This enzyme can be applied in its purified form but preferably as a whole-cell catalyst. Compared to the state of the art, whether it is the total synthesis or chemical modification, this new method represents a consider-able saving of costs and alleviation. The procedure can be used for the conversion of di- and tri-terpenes and opens therefore access to a high number of new substances.
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