NMDA Antagonists – New selective compounds to the NR2B subunit with high affinity
he NMDA receptor, an ion channel consisting of several protein subunits, is involved in the pathophysiology of chronic neurodegenerative diseases, depression, pain and alcoholism. Different subtypes of NMDA receptors can be categorized based on their subunit composition. The NR2B subunit expression is mostly localized in forebrain regions including cortex, hippocampus and striatum.
NR2B-selective antagonists have received considerable attention in recent years as they have shown efficacy in neuroprotection, anti-hyperalgesic and anti-Parkinson animal models. NR2B antagonists bind preferentially to the activated form of the NMDA receptor containing the NR2B subunit and allosterically modulate channel activity by inhibiting channel opening probability. They show advantages over non-selective NMDA receptor antagonists due to greater separation between efficacy and side effects.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 10
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Webb captures top of iconic horsehead nebula in unprecedented detail
NASA’s James Webb Space Telescope has captured the sharpest infrared images to date of a zoomed-in portion of one of the most distinctive objects in our skies, the Horsehead Nebula….
Cost-effective, high-capacity, and cyclable lithium-ion battery cathodes
Charge-recharge cycling of lithium-superrich iron oxide, a cost-effective and high-capacity cathode for new-generation lithium-ion batteries, can be greatly improved by doping with readily available mineral elements. The energy capacity and…
Novel genetic plant regeneration approach
…without the application of phytohormones. Researchers develop a novel plant regeneration approach by modulating the expression of genes that control plant cell differentiation. For ages now, plants have been the…
