Nematode Derived Cystatin Inhibits Allergic Airway Responses and Inflammation
A parasitic nematode derived cystatin (Av17) suppresses allergic airway responsiveness in a murine model of ovalbumin-induced allergy. This was combined with an overall down-regulation of effectors of allergic reactions such as IgE, eosinophils and Il-4. Furthermore, the filarial cystatin reduced inflammatory infiltrations and epithelial damage in a murine model of DSS-induced colitis.
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