Innovative method for detecting co-occurring histone modifications in a single step using hybrid proteins

Due to the role of epigenetics in a vast array of diseases, the study of epigenetic mechanisms has become one of the most rapidly growing fields of biology.
Amongst others, epigenetic alterations involve post-transcriptional histone modifications (PTMs). Occurring in complex patterns, they form the so-called ‘histone code’. In order to decipher said code and unravel its involvement in disease, the characterization of co-occurring histone modifications is considered to be an important cornerstone.
An innovative method now allows the detection of co-occurring histone modifications in one single step. Contrary to conventional methods, the technique offers much improved sensitivity, is easy to perform and features consistent quality.

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