GlioMethyl – Promotor methylation of the DUSP-4 gene as predictive parameter for gliomas
Gliomas, especially secondary glioblastomas, are affected
with hypermethylation of the promoter region of the DUSP4 gene. Further studies have shown a significant correlation between hypermethylation of DUSP4 and prolonged survival of glioblastoma patients. Similar correlation has also been observed with MGMT promoter methylation and treatment of Glioblastoma patients with alkylating agents. The present invention therefore provides a predictive epigenetic parameter for diagnosis or prognosis of gliomas and may be useful for prediction of the responsiveness to certain therapies. It further describes an improved method for the determination of the promoter methylation, which is applicable for the clinical setting. This invention provides an opportunity for the development of therapeutics for secondary glioblastomas.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 10
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Webb captures top of iconic horsehead nebula in unprecedented detail
NASA’s James Webb Space Telescope has captured the sharpest infrared images to date of a zoomed-in portion of one of the most distinctive objects in our skies, the Horsehead Nebula….
Cost-effective, high-capacity, and cyclable lithium-ion battery cathodes
Charge-recharge cycling of lithium-superrich iron oxide, a cost-effective and high-capacity cathode for new-generation lithium-ion batteries, can be greatly improved by doping with readily available mineral elements. The energy capacity and…
Novel genetic plant regeneration approach
…without the application of phytohormones. Researchers develop a novel plant regeneration approach by modulating the expression of genes that control plant cell differentiation. For ages now, plants have been the…