Coating of intraocular lens for after-cataract prophylaxis

Cataract is the leading cause of preventable blindness in elderly or diabetic patients worldwide. With a simple surgical technique, the opaque lens can be removed and replaced by an intraocular lens (IOL). The main complication of this procedure is the formation of an after-cataract in about 28 % of all patients after 5 years, resulting in the opacification of the posterior lens capsule. The reason

for PCO formation is the proliferation of residual lens epithelial cells, which attach to and migrate along the lens surface. <p> The current standard therapy for after-cataract is photodisruption of the posterior capsule by Nd:YAG laser, which can be associated with significant complications. Alternative lens designs with sharp edges were not able to significantly reduce overall cataract surgical costs. The numerous pharmacological approaches to prevent posterior capsule opacification have not led to clinical success. <p> A novel non-toxic coating with alkylphosphocholines for ophthalmological implants significantly reduces proliferation of residual lens epithelial cells and the resulting posterior capsule opacification. The coated lens could be implanted in a standard cataract surgery setting without additional requirements.

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