Biomarkers for diagnosis of delayed fracture healing
<strong>Background</strong><br>
Delayed or incomplete bone fracture healing can be observed in approximately 5–10% of patients following a fracture of the long bones. Known risk factors for delayed or incomplete healing are severe fractures, old age, steroid therapy or diabetes. No reliable blood or serum marker have been idenitified so far, which are applicable for predicting delayed fracture healing early in time. Osteocalcin, bone alkaline phosphotase and TGF beta have been investigated as predictive markers. However these parameters have only a limited validity for prediction due to a high intra-/ inter patients variability and/ or a late predictive time point.<br><br> <strong>Technology</strong><br> Recent findings suggest a key role of inflammation and T-cell response within the bone repair processes. The invention offers biomarkers for the prediction of delayed bone fracture healing by determining the frequency of two specific T-cell subpopulation from peripheral blood of patients. The frequency of T-cell subpopulations in peripheral blood can be measured with specific anti T-cell antibodies and fluorescence based flow cytometry. <br><br> <strong>Benefits</strong> Reliable biomarker for early predicting outcome of bone fracture healing allowing early interventions <br><br> <p><strong>IP Rights</strong><br> An European patent application was filed at the European Patent Office in February 2012<br> <br> <strong>Origin</strong><br> The technology was developed at theCharité – Universitätsmedizin Berlin(Germany).</p>
Further Information: PDF
ipal GmbH
Phone: +49 (0)30/2125-4820
Contact
Dr. Dirk Dantz
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Sea slugs inspire highly stretchable biomedical sensor
USC Viterbi School of Engineering researcher Hangbo Zhao presents findings on highly stretchable and customizable microneedles for application in fields including neuroscience, tissue engineering, and wearable bioelectronics. The revolution in…
Twisting and binding matter waves with photons in a cavity
Precisely measuring the energy states of individual atoms has been a historical challenge for physicists due to atomic recoil. When an atom interacts with a photon, the atom “recoils” in…
Nanotubes, nanoparticles, and antibodies detect tiny amounts of fentanyl
New sensor is six orders of magnitude more sensitive than the next best thing. A research team at Pitt led by Alexander Star, a chemistry professor in the Kenneth P. Dietrich…