Stimulating neurogenesis of adult neural stem cells by activating death receptor CD95
Optimizing the survival and differentiation of neural stem cells is one of the major goals in stem cell biology today. The present invention achieves this goal by the discovery that the ligand for CD95 (APO-1/Fas), namely, CD95L, induces neuronal differentiation in vitro and in vivo and use of CD95L compositions to effect differentiation. The present invention demon-strates that activation of CD95 can promote neurogenesis in neural stem cells (NSCs) in areas of neuronal damage or injury.
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