Secins – Cytohesin Inhibitors
Compounds for the inhibition of EGFR-signalling.
Invention: Pharmacological inhibition of cell proliferation, adhesion and migration is pivotal in the treatment of a wide variety of cancers. A prominent protein involved in these processes and associated with the onset of cancer in humans is the EGF receptor. It was surprisingly found by the inventors that cytohesins are a pathophysiologically relevant class of cytoplasmatic EGFR activators. Therefore, they are an attractive target for the modulation of different disease-relevant signal transduction pathways. A correlation of cytohesin expression with EGFR-signalling could already be shown for human lung adenocarcinoma. By cytohesin inhibition, therapeutic interventions may be possible in the future. The present invention discloses small molecules which combine a highly selective inhibitory effect on cytohesins with cell permeability and low toxicity.
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