polypeptdes, protease inhibitors and polyene antibiotics by means of defined polymeric micelles. The resulting micelles were small (rh up to 30 nm), had a narrow size distribution (PD up to 0.12) and both a high loading capacity of up to 45% w/w and a high loading efficiency of more than 80%. Solubility was increased up to multiple thousand folds for the compounds tested. Lyophilization was possible without use of a cryo-protectant. Cytotoxicity studies showed no toxicity up to 20 mg/ml polymer. Animal studies for micelles loaded drugs showed at least similar effect with regard to tumor inhibition compared to commercial available drug products.
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