benefits of this new principle are taste-masking, stabilisation of active ingredients for a prolonged storage time and protection of the mucous membrane in the oral cavity against irritation.
Different applications for this new method are possible. First of all, any pharmaceutical formulation with a pleasing taste would definitely be preferred over a competitor`s product and would translate into better compliance and therapeutic value for the patient. Second, stabilisation of active ingredients sensitive to moisture, oxygen or light is in the focus of drug development. Therefore, an ongoing need for coating of pellets exists. The aim of the present invention is to provide an economical process allowing the production of coated formulations while reducing costs and time of preparing the same. The invention comprises a simple process for generating solid pellets with an in-situ lipid coating, providing taste-masking or stabilising pharmaceutical formulations. With this self-coating procedure, a separate coating step of particulate formulations is thus no longer necessary.
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Dipl.-Ing. Alfred Schillert
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