Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mutation Detection - Highly sensitive detection of gene modifications/mutations

14.02.2013
articularly in oncology determination of gene mutation statuses serve as a biomarker to guide therapeutic decisions.

Scientists of the University of Duisburg-Essen developed an RT-PCR based test, with a sensitivity of up to 0.005% against a background of wild type alleles, detecting deletions and insertions as well as point mutations. The assay is robust and applicable in a broad range of laboratories. So far current methods for screening the epidermal growth factor-receptor (EGFR)-gene in patients with non-small lung cancer (NSCLC) require taking tumor biopsies. By applying this sensitive technology, it is possible to detect even one single mutated circulating tumor (CTC) cell per milliliter peripheral blood. As sequential biopsies or biopsies of multiple tumor lesions are not routinely performed due to patient safety, this opens new non-invasive possibilities for monitoring the mutation status of patients during treatment and to detect disease relapse early.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2954&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht Synthesis of novel Myrtucommulone and Analogues
25.11.2013 | TechnologieAllianz e.V.

nachricht Innovative nozzle design with homogeneous flow profile usable as divergent long-range nozzle with high penetration depth
22.11.2013 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Counting down to FEBS-EMBO 2014 in Paris, France

29.07.2014 | Event News

9th European Wood-Based Panel Symposium 2014 – meeting point for the wood-based material branch

24.07.2014 | Event News

“Lens on Life” - Artists and Scientists Explore Cell Divison

08.07.2014 | Event News

 
Latest News

Hubble Shows Farthest Lensing Galaxy Yields Clues to Early Universe

01.08.2014 | Physics and Astronomy

SwRI-led team’s research shows giant asteroids battered early Earth

01.08.2014 | Earth Sciences

Researchers uncover clues to flu’s mechanisms

01.08.2014 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>