Combined Application of Chimeric toxins and Saponin
Immunotoxins have to be administered in high doses due to low cytosolic
uptake with the consequence of severe side effects. An improvement for
immunotoxins was the development of a molecular adapter linking the toxic
and targeting moiety. Due to cleavable endosomal and cytosolic peptides the
adapter mediates cytosolic trapping of the toxin which leads to reduced side
effects on non-target dells in vitro. <br><br>
We offer a novel combination therapy that comprises the combined administration
of individually non-toxic concentrations of a chimeric toxin and the
triterpenoid saponin for an enhanced tumor cell-specific cytotoxic effect while
non-target cells are not affected at the effective concentration. The combination
therapy could be a new tool for the tumor therapy. Main characteristics
are: Lower required doses of immunotoxin, High cytotoxity and high specifity,
Reduction of undesired side effects.
<li>Tumor-specific targeting and extinction of tumor cells by chimeric toxins</li>
<li>Reduction of undesired adverse effects of systemic applications</li>
<li>Combination with saponins enhances rate of immunotoxin uptake and efficiency of chimeric toxin in target cells</li>
<li>Combined application allows doses reduction of cytotoxic agent and minimize adverse effects without impairing efficacy</li>
<li>Application in cell culture (ex vivo) and in mouse tumor model (in vivo) successfully tested
European Patent Applic. (07/2004) is granted soon<br>
PCT application (07/2005)<br>
Pending patent applications in Europe, Canada, USA and Japan
Charité - Universitätsmedizin Berlin<br>
Freie Universität Berlin
Further Information: PDF
Phone: +49 (0)30/2125-4820
Dr. Dirk Dantz
firstname.lastname@example.org | TechnologieAllianz e.V.
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
Oceans formed before Tharsis and evolved together, shaping climate history of Mars
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...