Pain may interfere with depression improvement
Treatment for depression may be stymied in people with moderate to severe body pain, according to a new study.
Researchers Matthew J. Bair, M.D., formerly of the Regenstrief Institute, and colleagues uncovered the connection by analyzing the results of a clinical trial of 573 depression patients taking medications like Prozac, Paxil or Zoloft. Their findings are published in the journal Psychosomatic Medicine.
Although depression improved in most of the patients after three months of drug therapy, 24 percent had persistently high depression scores. The therapy was most likely to fail among those who reported moderate to severe pain at the beginning of their treatment.
“In particular, the odds of a poor depression treatment response were twice as high in patients with moderate pain at baseline and three to four times as high in those with severe pain,” Bair says.
Factors like pain may help explain why antidepressants have a mixed record of success, Bair says. Between 50 and 70 percent of depressed patients find only partial relief with their medications.
Researchers have long known that pain and depression often go hand in hand, but there are few studies of how pain might affect depression treatment. In the Bair study, more than two-thirds of the patients reported some degree of pain at the start of their treatment. Twenty-five percent said their pain was mild, 30 percent had moderate pain and 14 percent said they had severe pain.
“We believe a treatment model that incorporates assessment and treatment of both depression and pain is desirable,” Bair says.
The study was supported by the Health Resources and Service Administration and Eli Lilly and Co.
Health Behavior News Service: (202) 387-2829 or www.hbns.org.
Interviews: Contact Matthew Bair at firstname.lastname@example.org.
Psychosomatic Medicine: Contact Victoria White at (352) 376-1611, ext. 5300, or email@example.com. Online, visit www.psychosomaticmedicine.org.
Becky Ham | Health Behavior News Service
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...