Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers identify tissue biomarker for dementia with lewy bodies and Parkinson's disease

12.04.2016

New research reported in the Journal of Parkinson's Disease

Accurate diagnosis of Parkinson's disease, and the related disease "dementia with Lewy bodies," can be difficult in the early stages of both conditions. While brain biopsies can be more accurate, the risk of complications has been considered too high.


The black fiber is positive for alpha-synuclein pathology inside a nerve fiber in the submandibular gland.

Credit: Journal of Parkinson's Disease

New research published in the Journal of Parkinson's Disease indicates that a biopsy of the submandibular gland can help identify the same pathology that is seen in the brain, providing some of the increased accuracy of brain biopsy, but not the increased risk.

Investigators had previously shown, first in autopsies and then with biopsies, that the submandibular gland, the saliva-producing gland in the neck, has the signature alpha-synuclein microscopic pathology of Parkinson's disease and that the gland can be biopsied to provide an unambiguous confirmation of diagnosis.

"This new work shows, in autopsies, that the submandibular gland also has the same signature alpha-synuclein pathology in a high proportion of subjects diagnosed during life with dementia with Lewy bodies. Biopsy of the submandibular gland then also may be able to provide a more accurate diagnosis of dementia with Lewy bodies during life," explained lead investigator Thomas G. Beach, MD, PhD, Head and Senior Scientist at the Civin Laboratory for Neuropathology, Director of the Brain and Body Donation Program, Banner Sun Health Research Institute (BSHRI), Phoenix, Arizona.

Lewy-type α-synucleinopathy (LTS) is found in the brains of all Parkinson's disease patients when they are autopsied. For a number of other diseases related to Lewy bodies, this same pathology is present. This study involved subjects with central-nervous-system Lewy-type diseases and a control group without Lewy-type pathology. Both groups were comprised of elderly subjects who had volunteered for the Arizona Study of Aging and Neurodegenerative Disorders and the Brain and Body Donation Program (BBDP).

When LTS is present, it is possible to see it by using an immunohistochemical staining technique. In the image, the dark line is a nerve fiber in the submandibular gland, made visible with the stain. This finding was not observed in normal control subjects.

In this study, submandibular gland alpha-synuclein pathology was found in 42/47 (89%) of autopsies of individuals with Parkinson's disease and 20/28 (71%) of those with dementia with Lewy bodies, but in none of the 110 control subjects.

The subjects had a variety of conditions. Those with Lewy body disorders included 46 with Parkinson's disease, 28 with dementia with Lewy bodies (DLB), nine with incidental Lewy-body disease, 33 with Alzheimer's disease with Lewy bodies, and two with progressive supranuclear palsy with Lewy bodies (PSPLB). Control subjects, defined as individuals without central-nervous-system LTS, included 79 normal elderly subjects, 15 with Alzheimer's disease, 12 with progressive supranuclear palsy, two with corticobasal degeneration and two with multiple system atrophy (MSA).

In the specific case of DLB, Dr. Beach emphasized that this study is important because, "The low diagnostic accuracy, during life, for dementia with Lewy bodies, has made it difficult to conduct effective clinical trials of possibly helpful new drugs. With better diagnostic accuracy, clinical trials would have a higher chance of success and could be done more quickly and at lesser cost. The next step will be to do biopsies of the submandibular gland in living people with dementia with Lewy bodies to confirm these autopsy results."

Media Contact

Daphne Watrin
d.watrin@iospress.nl
31-206-883-355

 @IOSPress_STM

http://www.iospress.com 

Daphne Watrin | EurekAlert!

Further reports about: biopsies dementia dementia with Lewy bodies diagnostic accuracy

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

The interactome of infected neural cells reveals new therapeutic targets for Zika

23.01.2017 | Life Sciences

Melting solid below the freezing point

23.01.2017 | Materials Sciences

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

VideoLinks
B2B-VideoLinks
More VideoLinks >>>