Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Found in translation: Prioritising research questions in breast cancer

22.11.2007
The key priorities that will impact on the future treatment of breast cancer have been identified by a group of experts on the disease. Research published in the online open access journal Breast Cancer Research may focus research resources onto the issues highlighted as top priorities.

A team led by Professor Mitch Dowsett, Head of Biochemistry at The Royal Marsden NHS Foundation Trust, based in London and Surrey, together with colleagues from the USA, Switzerland and Italy carried out an international, web-based consultation to identify the most pressing issues that could be tackled by translational research. Translational research - which is concerned with the transfer of findings from the lab to the clinic - holds huge promise for the individualisation of cancer treatment.

In this study, a database of over 4000 potential participants (breast cancer professionals, including clinicians, research scientists, academics and pathologists) was created using attendee details from two major breast cancer conferences, one held in the USA and one in Europe. Participants were asked to register online and then log the most important questions that they felt the research community should tackle.

A steering committee reduced the 409 questions registered to 70 unique issues, from which participants were asked to vote for their 'top six'. In all, 420 participants from 48 countries voted; around half of voters classed themselves as clinicians.

The top research priority found was the identification of molecular signatures to select patients who could be spared chemotherapy. The second most pressing issue also involved chemotherapy, namely the identification of features to help clinicians choose the optimal chemotherapy regimen for individual patients.

While translational research in breast cancer has increased greatly over recent years, individual projects often reflect the immediate interests of the research group, rather than attempting to answer a specific question with potential to alter patient management. Identifying issues deemed important by the research community could help focus translational research resources, ensuring that opportunities for important clinical advances aren't missed.

"This appears to be a novel way to identify the most important challenges for improving breast cancer treatment and prevention" explains Professor Dowsett. "The work will allow investigators globally to select the most relevant clinical research questions in their efforts to translate the major advances in basic science to improvements in the clinical management of this common malignancy. I am grateful to the participants from 48 countries who made this possible."

Charlotte Webber | alfa
Further information:
http://www.biomedcentral.com

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>