Dipyrone may treat headaches – but use with caution: New Findings from The Cochrane Library
The controversial drug dipyrone can treat acute headaches, but patients should be warned of the risk of potentially serious blood disorders (or “dyscrasias”), concluded a Cochrane Review team. Furthermore, most of the studies used in reaching this conclusion involved intravenous infusions of the drug, making it expensive and complex to deliver.
Dipyrone is a non-opioid painkiller that was launched in Germany in 1922 but was later banned from many countries including the USA and UK because of evidence that it might cause life-threatening blood disorders such as agranulocytosis. It is, however, a popular analgesic in many parts of the world including South America, India, South Africa, Russia and several European countries. Oral doses can be bought over the counter in Brazil and Spain.
A group of Cochrane Researchers set out to evaluate whether dipyrone was effective and safe for acute primary headaches in adults and children.
They identified four trials that involved 636 adults. None involved children. Three of the studies used intravenous dipyrone.
Taken together the evidence indicates that dipyrone is effective in treating episodic tension-type headaches and migraine in adults. The sample size, however, was too small to make any assessment of the medicine’s safety.
“Given that many effective and more easily administered therapies are available, patients and clinicians will need to consider whether and in what circumstances the benefits of treatment are worth the time, trouble and expense of intravenous administration,” says Dr Rebecca Gray, a Cochrane Editor who worked closely with the project.
If used, “patients should be well informed about the risk of blood dyscrasias,” she adds.
Jennifer Beal | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...