Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Malaria poses additional risks for first-time mothers

14.11.2006
One of the consequences of malaria has been shown in new research to be an increased likelihood for women in their first pregnancy to develop preeclampsia (very high blood pressure and protein loss in the urine), which carries high risks for both mother and child.

Preeclampsia is thought to be more common in parts of the world where there is a serious malaria problem and it has often been speculated that there might be a connection. Malaria is more common in a first pregnancy and so is preeclampsia. In both cases, the reasons are unknown. Researchers from the USA, UK and Tanzania set out to investigate the possibility that malaria might lead to preeclampsia.

When a pregnant woman has malaria, it can result in a high concentration of malaria parasites developing in the placenta, in which case she is said to have ‘placental malaria’. This is very harmful to the mother and to the fetus; it leads to low birth weight and, in Africa alone, is estimated to be responsible for the deaths of about 200,000 infants every year. A woman who is pregnant for the first time is most likely to suffer from placental malaria, and to have her placenta become highly infected and extremely inflamed. If she later becomes pregnant again, she will be protected to some extent by antibodies she has developed against the parasites in the placenta.

Working with pregnant women in Tanzania, the researchers found that, overall, women with placental malaria were no more likely than other women to develop hypertension. However, for young first-time mothers, having placental malaria increased the risk of hypertension about three-fold. The researchers also measured levels of a substance called sVEGFR1 (sometimes called sFlt1), which is known to increase before and during preeclampsia and is thus considered to be a ‘biomarker’ for the condition. sVEGFR1 levels were high in first-time mothers with either placental malaria or hypertension, or both, but levels were not raised in other mothers with these conditions. A related substance, VEGF, which is known to be involved with the process that causes inflammation, was high in first-time mothers with placental malaria, but not in those who had hypertension alone. sVEGFR1 can bind to VEGF and block its action.

Because sVEGFR1 was produced by the fetus’ cells, and VEGF was produced by the mother’s cells, the scientists concluded that the mother and fetus were in conflict over how to deal with the parasites in the placenta, and that this conflict led to preeclampsia.

The researchers say their findings support the view that, in young first-time mothers only, placental malaria can cause preeclampsia. Action to reduce the chance of such women getting malaria would have the additional benefit of lowering their chance of developing preeclampsia.

Citation: Mutabingwa TK, Bolla MC, Li JL, Domingo GJ, Li X, et al. (2005) Maternal malaria and gravidity interact to modify infant susceptibility to malaria. PLoS Med 3(11): e407.

Andrew Hyde | alfa
Further information:
http://www.plosmedicine.org
http://dx.doi.org/10.1371/journal.pmed.0020407

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>