Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High Blood Sugar Levels a Risk Factor for Heart Disease

13.09.2005


Diabetics and Non-Diabetics at Increased Risk



Lowering blood sugar levels could reduce the risk of coronary heart disease in both diabetics and non-diabetics, according to researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions. The researchers found that Hemoglobin A1c (HbA1c)—a measure of long-term blood glucose level—predicts heart disease risk in both diabetics and non-diabetics. An elevated blood glucose level is the defining feature of diabetes, but until now it was unclear whether elevated glucose levels contributed independently to increasing heart-disease risk. The study is published in the September 12, 2005, issue of Archives of Internal Medicine.

“In persons with diabetes, we know that traditional cardiovascular risk factors, such as hypertension and high cholesterol, should be treated aggressively. Our results also suggest that improving blood-glucose control may further reduce heart disease risk,” said Elizabeth Selvin, PhD, MPH, lead author of the study and a postdoctoral fellow in the Bloomberg School of Public Health’s Department of Epidemiology. “For non-diabetics, lifestyle modifications, such as increased physical activity, weight loss and eating a healthful, low-glycemic, index diet rich in fiber, fruit and vegetables, may not only help prevent diabetes, but also reduce the risk of heart disease,” she said.


The researchers used data from the Atherosclerosis Risk in Communities Study (ARIC), a community-based cohort of almost 16,000 people from four states—North Carolina, Mississippi, Maryland and Minnesota. HbA1c levels were taken from ARIC study participants during clinical examinations in 1990-1992. ARIC researchers tracked study participants for 10-12 years to acquire coronary heart disease events, hospitalizations and deaths.

In participants with diabetes, the researchers found a graded association between HbA1c and increasing coronary heart disease risk. Each 1-percentage-point increase in HbA1c level was associated with a 14 percent increase in heart disease risk. According to the study authors, the current target for “good” glycemic control established by the American Diabetes Association is an HbA1c value less than 7 percent. However, the researchers’ analyses suggest that heart disease risk begins to increase at values even below 7 percent.

They found that those study participants without diabetes but who had “high normal” HbA1c levels (approximately 5 percent to 6 percent) were at an increased heart disease risk, even after accounting for other factors such as age, cholesterol level, blood pressure, body mass index and smoking. Non-diabetic persons with HbA1c levels of 6 percent or higher had almost a two-fold greater heart disease risk compared to persons with an HbA1c level below 4.6 percent.

“There are large, on-going clinical trials which should definitively answer the question of the effectiveness of blood glucose-lowering medications in decreasing cardiovascular risk in persons with type-2 diabetes. But our results suggest we should also be concerned about elevated blood sugar levels in non-diabetics as well. An important next step is to investigate strategies for lowering HbA1c in persons without diabetes,” said Selvin.

The study authors were supported in part by grants from the National Heart, Lung, and Blood Institute.

Co-authors of the study are Elizabeth Selvin, Josef Coresh, Sherita H. Golden, Frederick L. Brancati, Aaron R. Folsom and Michael W. Steffes.

Public Affairs media contacts for the Johns Hopkins Bloomberg School of Public Health: Kenna Lowe or Tim Parsons at 410-955-6878 or paffairs@jhsph.edu.

Kenna L. Lowe | EurekAlert!
Further information:
http://www.jhsph.edu

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>