Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Patients with osteoporosis should be screened for celiac disease

01.03.2005


Rates of celiac disease are significantly higher in patients with osteoporosis, according to researchers at Washington University School of Medicine in St. Louis. They recommend using blood tests to screen osteoporosis patients for celiac disease because their study has shown that treating celiac disease with diet can restore bone health in these patients.



Celiac disease is an intestinal disorder caused by intolerance to wheat flour (gluten). The investigators evaluated 840 people, 266 patients with osteoporosis and 547 without the bone disease. Through blood tests and endoscopic intestinal biopsies, they found nine osteoporosis patients also had celiac disease compared to only one of the 574 patients who didn’t have osteoporosis.

"Our results suggest that as many as three to four percent of patients who have osteoporosis have the bone disease as a consequence of having celiac disease, which makes them unable to absorb normal amounts of calcium and vitamin D," says principal investigator William F. Stenson, M.D., a Washington University physician at Barnes-Jewish Hospital. The study is reported in the Feb. 28 issue of the Archives of Internal Medicine.


In celiac disease, an immune reaction to the gluten portion of wheat interferes with the intestine’s absorption of various dietary products. The disease can contribute to malnutrition and gastrointestinal problems. Removing gluten from the diet by excluding certain grain products corrects the condition. Although celiac disease often involves obvious symptoms such as weight loss and diarrhea, some patients do not know they have the disease because they experience only subtle problems such as iron deficiency anemia.

By putting patients who had celiac disease and osteoporosis on a gluten-free diet for one year, the investigators were able to improve gastrointestinal symptoms and improve bone density as well. "Bone density -- which is the way bone health is measured -- improved dramatically on a gluten-free diet," Stenson says. "We believe the diet allowed intestines to heal and that permitted normal absorption normal of calcium and vitamin D to reverse bone loss."

The improvement in bone density was greater than would have been expected for patients with osteoporosis on standard therapy.

Stenson, a professor of medicine at Washington University, says it’s not clear how common celiac disease is in the general population, but most health professionals believe the rate is higher than was previously thought. Celiac disease is detected much more in children than it once was, but Stenson says adults can develop the disease, too. "There is a genetic predisposition for celiac disease," he says. "But many people don’t develop symptoms until later in life when they are exposed to something that triggers those genes to launch the disease."

In this study, only 0.2 percent of people with healthy bones also had positive blood tests for celiac disease. The rate in people with osteoporosis was 4.5 percent. So Stenson and colleagues are recommending that when a patient is treated for osteoporosis, it might be worthwhile for their doctor to also order a blood test for celiac disease.

"One of our conclusions is that the incidence of celiac disease in patients with osteoporosis is high enough to justify screening for everybody with osteoporosis," Stenson says. "The idea is that if a patient has osteoporosis as a consequence of celiac disease, the most direct way to correct their bone loss would be to put them on a gluten-free diet."

Jim Dryden | EurekAlert!
Further information:
http://www.wustl.edu

More articles from Health and Medicine:

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>