Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Magnetic Resonance Imaging Significantly Better than Mammography for Detecting Number and Size of Tumors in Breast Cancer

08.06.2004


Researchers from the Abramson Cancer Center of the University of Pennsylvania today presented the first comprehensive study results which show that magnetic resonance imaging (MRI) is significantly better than traditional mammography for detecting the presence and extent of disease in patients with a diagnosis of breast cancer. The research has significant implications for women considering surgical options – other than a full mastectomy – to remove their breast cancer, such as a lumpectomy. Indeed, an MRI is recommended for all women considering surgical options, in order to detect the full extent of the breast cancer prior to surgery, yet preserve as much healthy breast tissue as possible. Abramson researchers led the first international, multi-site group of researchers to study the subject – the International Breast MRI Consortium (IBMC) – and presented their results at the 40th Annual Meeting of the American Society for Clinical Oncology in New Orleans.

“There has never really been a gold standard for detecting how many tumors or how widespread is a women’s breast cancer,” said study principal investigator and professor Mitchell Schnall, MD, PhD, a radiologist at the Cancer Center and chief of the MRI section at the University of Pennsylvania Medical Center. “These study results are very conclusive that breast MRI works better for detecting breast cancer, and physicians – when evaluating surgical options for breast conservation – should be using MRI over traditional mammography with physical exam for determining how widespread the tumors are and how much tissue really needs to be removed.”

The study – at 17 different sites throughout the US, Canada and Germany – examined more than 1000 women, most of whom were over the age of 40, for a period of three years. All of the women had suspicious lesions on their mammograms, which required further investigation to see if cancer was present. Each participant had both follow-up mammograms and MRIs. Cancer was confirmed by a biopsy, surgical removal and microscopic examination of the tissue. Of the 428 women who had breast cancer, MRI detected additional cancerous lesions in 56 women, while mammograms detected additional lesions in only 17. In statistical terms, MRI was more than 2 times as effective than mammography in detecting multiple tumors.



Prior to this international study, only single-site data was available and, due to small populations (less than 100 women) and the increased potential for single-population bias, the results could not be considered conclusive.

“The impact for patient care is significant,” said Schnall. “Because MRI is so sensitive at detecting as much of the breast cancer as possible, we can hopefully improve the effectiveness of lumpectomy by reducing the rate of recurrence of breast cancer.”

“Additionally, if we capture more of the cancer at the time of detection, there will be less of a need for radiation therapy after surgery – allowing for fewer side effects from treatment.”

Current statistics for the recurrence of breast cancer – after breast conservation therapy, such as lumpectomy – are three to 19 percent after ten years. Preventing recurrence is strongly linked to removing all tumors, through full surgical margins (the amount of surrounding tissue that is removed along with the tumor) and accurate detection of cancerous tissue.

MRI is a non-invasive procedure that uses powerful magnets and radio waves to construct pictures of the body. Unlike conventional X-rays, MRI imaging uses the magnetic properties of atoms to differentiate organs, and contrast benign and malignant tissue. Imaging planes (or "slices") from any part of the body can be projected, stored in a computer, or printed on film. MRI can easily be performed through clothing and bones.

Funding for the study was provided through a research grant in 1997 from the National Cancer Institute that totaled nearly $5 million. At the time, it was the largest grant ever awarded for breast MRI research.

The American Cancer Society estimates that in 2004 over 200,000 American women (11,000 in Pennsylvania alone) will be diagnosed with breast cancer and 40,000 will die from the disease.

Rebecca Harmon | UPMC
Further information:
http://www.uphs.upenn.edu/news/News_Releases/june04/MRIBreastCancer.html

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>