Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A new antibiotic improves treatment of parasitic infections

13.02.2004


A team of researchers from the Universitat Autònoma de Barcelona, lead by Professor Jordi Alberola, has demonstrated the efficacy and safety of a new type of antibiotic, belonging to the family called antimicrobial peptides, for treating canine leishmaniasis, which is a disease that also affects humans. It is the first time that these antibiotics have been demonstrated to be useful against parasitic diseases in real clinical situations. The antibiotic can also improve treatment of other infections, parasitic or not, in that no side effects have been observed and it is very difficult for organisms to develop resistance to them. In addition, it can also have a direct application as a drug for treating co-infection of leishmaniasis with HIV, which 10 % of people with AIDS suffer from. The findings will be published this month (February) in the magazine Antimicrobial Agents and Chemotherapy, which is the most prestigious in its field.



Twelve million people around the world are affected by leishmaniasis; 400 million more are at risk of suffering the disease and every year between 60,000 and 100,000 people die from it. Furthermore, nearly 2 million new cases are reported every year. The different forms of leishmaniasis are caused by unicellular parasites of the Leishmania genus, which are mainly spread by biting insects, similar to mosquitoes, called phlebotoms. Clinical manifestations range from slight cutaneous lesions to visceral complications that may lead to the individual’s death.

Dogs are the main reservoir of the parasite in Spain and in the rest of the Mediterranean basin, the Middle East and South America. Epidemiological studies show that around 70% of dogs in the Mediterranean area are infected. Consequently, eradication of the disease in dogs is considered to be one of the main objectives for improving human health.


A team of researchers at the Universitat Autònoma de Barcelona headed by Professor Jordi Alberola of the Department of Pharmacology, Therapeutics and Toxicology, working in collaboration with researchers at the Pompeu Fabra University and the CSIC [Spanish Council for Scientific Research] have described, for the first time, the safety and efficacy of a new type of antibiotic from the antimicrobial peptide family, little studied up until now, against canine leishmaniasis. These latter researchers had already demonstrated the efficacy in laboratory cell cultures, but the efficacy in real clinical situations against parasitic diseases had never been demonstrated.

The researchers have obtained very promising results in a preliminary study on 8 dogs affected by the disease: no adverse affects were detected; the parasitic load is decreased, and it seems to have long term effects, which could be very useful for use in therapies applied to people or animals that live in areas where medicines cannot easily be shipped to (as is the case in the principal areas affected by leishmaniasis).

One of the most direct applications of the antibiotic would be its use as a drug for treating co-infection of leishmaniasis and HIV. This new type of infection affects approximately 10 % of people who have AIDS, but in the case of the risk group made up of intravenous drug users it may be as high as 70%.

The research findings will be published this month (February) in the magazine Antimicrobial Agents and Chemotherapy, the most prestigious in its field. The findings were carried out in collaboration with Laboratorios Calier S.A and researchers at the Pompeu Fabra University and by the Spanish Council for Scientific Research (CSIC).

Octavi López Coronado | alfa
Further information:
http://www.uab.es

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>