Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Donor immune cells attack metastatic breast cancer

03.06.2003


In patients with metastatic breast cancer, immune cells from a genetically matched donor can attack and shrink tumors, researchers from the National Cancer Institute (NCI) announced today at the Annual Meeting of the American Society of Clinical Oncology in Chicago. This is the first time researchers have clearly demonstrated this type of immune response, known as a graft-versus-tumor effect, acting against breast cancer.


"Graft-versus-tumor effects have been shown to be useful in treating cancers of the blood, such as leukemia and lymphoma. Breast cancer, however, has generally been resistant to immune-based therapies," said Michael Bishop, M.D., of NCI’s Center for Cancer Research, the lead author on the study. "Although the tumors of patients in this study were not completely eliminated by the treatment, the responses we saw provide hope that immunotherapies for breast cancer are worth pursuing."

Tumor regression has been observed in the past in some patients with metastatic breast cancer who received stem cell transplants, but it was unclear whether immune cells had attacked the tumor or the tumor was shrinking in response to chemotherapy drugs administered prior to the transplant. The design of this clinical trial, however, allowed researchers to attribute tumor regression to a true graft-versus-tumor effect.

Each of the 13 patients in the Phase I trial had received multiple previous treatments for metastatic breast cancer. In the study, patients first received conventional doses of chemotherapy to kill cancer cells and reduce the cells in their immune system so that donor cells could replace them. They then received stem cells from the blood of HLA-matched siblings. HLA-matched donor cells, which have the same set of proteins (known as human leukocyte-associated antigens) on their surface as the patient’s own cells, are much more likely to be accepted by the patient’s body.



T cells, specialized immune cells that recognize and kill foreign cells that have invaded the body, were removed from the pool of donated stem cells prior to transplant. These T cells were given to patients later, in an initial infusion 42 days after stem cell transplant, then in two follow-up infusions over the next two months. Because T cells were not given immediately following chemotherapy, researchers were able to attribute any tumor cell death to the transplanted T cells rather than to anti-tumor effects of the chemotherapy drugs.

In four patients, tumors shrunk at least 50 percent in response to the treatment. A minor response was seen in three of the other patients. Although not all patients in the study responded to treatment, and none of the tumors was eliminated entirely, the results of the trial provide evidence that transplanted T cells can attack tumors in patients with metastatic breast cancer. Researchers are optimistic that further study could lead to effective immunotherapies for these patients.

NCI Press Office | EurekAlert!
Further information:
http://www.cancer.gov

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Midwife and signpost for photons

11.12.2017 | Physics and Astronomy

How do megacities impact coastal seas? Searching for evidence in Chinese marginal seas

11.12.2017 | Earth Sciences

PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems

11.12.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>