Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jackson researchers identify a gene implicated in oxidative stress and neurodegeneration

26.09.2002


Oxidative stress is implicated in a fast-growing list of human conditions, from the superficial (e.g., wrinkled skin) to the deadly: diseases such as cancer, heart disease and neurodegenerative disorders including Lou Gehrig’s disease (amyotrophic lateral sclerosis or ALS).



Researchers at The Jackson Laboratory announced that they have located a gene that protects certain brain and retinal neurons from oxidative stress, and prevents neurodegeneration.

Many normal metabolic functions produce free radicals--highly unstable forms of oxygen. Despite their notoriety, these molecules in fact have several beneficial roles, such as helping white blood cells attack bacteria, viruses and virus-damaged cells. Oxidative stress occurs when the amount of free radicals exceeds the normal antioxidant capacity of a cell, leading to cell damage.


The research team, headed by Staff Scientist Susan Ackerman, Ph.D., discovered that mice from a strain called harlequin have a mutation in the apoptosis-inducing factor (Aif) gene, causing a severe reduction in AIF production. The AIF protein serves as a scavenger of free radicals in certain brain and retinal neurons. Because harlequin mice have much lower levels of AIF, neurons in these mice undergo oxidative stress. The researchers demonstrate that oxidative stress causes neurons to duplicate their DNA in a process known as re-entering the cell cycle. But the neurons cannot successfully divide. They die in the attempt.

The results of Dr. Ackerman’s team’s work, published in the journal Nature, provide a genetic model of neurodegeneration mediated by oxidative stress. They also demonstrate a direct connection between cell cycle re-entry and oxidative stress in an aging central nervous system.

To date, ALS is the one neurodegenerative disorder known to be caused by oxidative damage to neurons. However, oxidative stress has been identified as a possible cause of several later-onset neurodegenerative diseases, and there are also indications that the diseased neurons of Alzheimer’s patients have duplicated their DNA prior to dying.

The harlequin mouse provides the first model for studying the role of oxidative stress on aberrant cell cycle reentry and subsequent death of neurons.

Joyce Peterson | EurekAlert!
Further information:
http://www.jax.org/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

Information integration and artificial intelligence for better diagnosis and therapy decisions

24.05.2017 | Information Technology

CRTD receives 1.56 Mill. Euro BMBF-funding for retinal disease research

24.05.2017 | Awards Funding

VideoLinks
B2B-VideoLinks
More VideoLinks >>>