Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Skin test may detect subarachnoid hemorrhage risk

06.09.2002

A skin test can detect a tissue disorder that may increase the risk of intracranial aneurysm, which can lead to stroke, according to a pilot study published in the September Stroke: Journal of the American Heart Association. Researchers found defects in the structural matrix of skin tissue in 33 percent of study patients with intracranial aneurysms.

Aneurysms are weakened sections of blood vessels that balloon out from the artery wall. When they rupture, they can cause a type of stroke known as subarachnoid hemorrhage – bleeding in the brain.

"Our findings suggest that people with multiple aneurysms have a predisposing connective tissue disorder, leading to a weakness of the artery wall," says Caspar Grond-Ginsbach Ph.D. "This disorder can be diagnosed by a skin test."

Grond-Ginsbach, a geneticist and Holger Schnippering, M.D., a neurosurgeon, both at the University of Heidelberg in Germany, are lead authors of the report.

About 3 percent to 6 percent of adults age 30 and older have unruptured aneurysms and about 20 percent of them have multiple artery weaknesses, they say. Genes play a role in the development of some intracranial aneurysms, but why these aneurysms develop remains unknown. The findings suggest a genetic cause for two connective tissue defects.

Several years ago, the researchers discovered connective tissue defects in patients with cervical artery dissections, another vascular defect that causes stroke. They initiated this study because dissections and aneurysms might be related, they say.

Biopsies from the arterial wall of patients are rarely available, Grond-Ginsbach explains. Skin is considered a window to heritable connective tissue disorders, so researchers took skin samples from patients’ upper arms. They used an electron microscope to examine the collagen and elastic fibers of the skin.

The team took skin biopsies from 21 patients with intracranial aneurysm (average age 44) without signs of connective tissue disorders. Seventeen of them had suffered a subarachnoid stroke.

They found that seven patients had connective tissue mutations. These tissue alterations were not found in 10 patients who did not have intracranial aneurysms or in a database of more than 3,000 patients who had skin biopsies to diagnose dermatological problems. Four patients were classified as normal, although their electron microscope examinations seemed somewhat abnormal. So these findings might be an underestimation.

The researchers caution however, that the test is a scientific test rather than a screening tool for patient management.

Carole Bullock | EurekAlert

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>