A skin test can detect a tissue disorder that may increase the risk of intracranial aneurysm, which can lead to stroke, according to a pilot study published in the September Stroke: Journal of the American Heart Association. Researchers found defects in the structural matrix of skin tissue in 33 percent of study patients with intracranial aneurysms.
Aneurysms are weakened sections of blood vessels that balloon out from the artery wall. When they rupture, they can cause a type of stroke known as subarachnoid hemorrhage – bleeding in the brain.
"Our findings suggest that people with multiple aneurysms have a predisposing connective tissue disorder, leading to a weakness of the artery wall," says Caspar Grond-Ginsbach Ph.D. "This disorder can be diagnosed by a skin test."
Grond-Ginsbach, a geneticist and Holger Schnippering, M.D., a neurosurgeon, both at the University of Heidelberg in Germany, are lead authors of the report.
About 3 percent to 6 percent of adults age 30 and older have unruptured aneurysms and about 20 percent of them have multiple artery weaknesses, they say. Genes play a role in the development of some intracranial aneurysms, but why these aneurysms develop remains unknown. The findings suggest a genetic cause for two connective tissue defects.
Several years ago, the researchers discovered connective tissue defects in patients with cervical artery dissections, another vascular defect that causes stroke. They initiated this study because dissections and aneurysms might be related, they say.
Biopsies from the arterial wall of patients are rarely available, Grond-Ginsbach explains. Skin is considered a window to heritable connective tissue disorders, so researchers took skin samples from patients upper arms. They used an electron microscope to examine the collagen and elastic fibers of the skin.
The team took skin biopsies from 21 patients with intracranial aneurysm (average age 44) without signs of connective tissue disorders. Seventeen of them had suffered a subarachnoid stroke.
They found that seven patients had connective tissue mutations. These tissue alterations were not found in 10 patients who did not have intracranial aneurysms or in a database of more than 3,000 patients who had skin biopsies to diagnose dermatological problems. Four patients were classified as normal, although their electron microscope examinations seemed somewhat abnormal. So these findings might be an underestimation.
The researchers caution however, that the test is a scientific test rather than a screening tool for patient management.
Carole Bullock | EurekAlert
Malaria Already Endemic in the Mediterranean by the Roman Period
27.07.2017 | Universität Zürich
Serious children’s infections also spreading in Switzerland
26.07.2017 | Universitätsspital Bern
Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.
Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
26.07.2017 | Event News
21.07.2017 | Event News
19.07.2017 | Event News
27.07.2017 | Life Sciences
27.07.2017 | Life Sciences
27.07.2017 | Health and Medicine