Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


First pregnancies reported using a new, needle-free device for administering hormones to IVF women


Fear of needles and the discomfort of daily injections could soon be a thing of the past for women undergoing IVF treatment thanks to a new device which can administer hormones without a needle injection.

Dr Stuart Lavery, a Subspeciality Fellow in Reproductive Medicine and Surgery at the Hammersmith Hospital in London, UK, told the European Society of Human Reproduction and Embryology conference in Vienna today (Wednesday 3 July) that a team at the hospital had achieved the first pregnancies using the needle-free device which is called a J-Tip.

To retrieve eggs from the ovary of a woman undergoing IVF treatment, doctors have to stimulate the ovaries to go into overdrive and produce several follicles (groups of cells) containing the eggs. They do this by injecting hormones into the woman over a period of time before they perform the operation to retrieve the follicles. For women who are "needle-phobic" the regular injections can be a problem.

The J-Tip is a single-use, disposable device, capable of delivering a liquid therapeutic agent under the skin. It is about 10 cms long and it works by using a compressed carbon dioxide gas cartridge to propel the medication, under high pressure, through the skin into the subcutaneous layer below. The high pressure enables the medication itself to pierce the skin, thereby avoiding the use of a needle.

The team led by Mr Geoffrey Trew, a consultant gynaecologist at the Hammersmith, tested the J-Tip on 20 patients between the ages of 20 and 38 years old, who were undergoing IVF treatment, to see how effective it was in prompting controlled ovarian hyperstimulation. They also wanted to test how easy it was to use, how acceptable it was to the patients and whether its use could result in pregnancies.

Nurses used the J-Tip to deliver recombinant follicle stimulating hormone (Puregon NV Organon) to the women once a day for an average of 10 days. Subsequently the researchers were able to retrieve an average of 12 eggs each from 16 of the 20 women. The treatment of one patient was cancelled due to poor response, one was cancelled due to the number of technically incorrect J-Tip injections, and two women asked to withdraw from the study. As a result of successful egg collection, four of the women then became pregnant.

Dr Lavery said: "The results in this small study were reassuringly comparable with conventional techniques in terms of number of eggs collected and pregnancy rates. This is the first time that the J-Tip has been used in reproductive medicine and we can report the first pregnancies achieved using this system. The study shows that the J-Tip is capable of delivering hormones in a new and less invasive way.

"The development of a needle-free injection system is an important target in the improvement of patient convenience in IVF, where the drug treatment phase can require daily injections for several weeks, which for many can be a stressful experience, particularly for those who have a fear of needles. Although nurses administered the J-Tip injections, the ultimate aim is for the patients to be able to do it themselves. Diaries kept by patients during their treatment indicated a high level of patient acceptance of the J-Tip. All the women had undergone conventional IVF cycles previously and their diaries indicate a clear preference for the needle-free approach."

Abstract no: O-203 (Wednesday 10.00hrs CET Hall A) URL:

Note: A costing on the J-Tip device is still in development.

Further information:
Margaret Willson, information officer
Tel: +44 (0) 1536 772181
Fax: +44 (0) 1536 77219
Mobile: +44 (0) 7973 853 347

Emma Mason, information officer
Tel: +44 (0) 1376 563090
Fax: +44 (0) 1376 563272
Mobile: +44 (0) 7711 296 986

Press Office: (Sunday 30 June – Wednesday 3 July)
Margaret Willson, Emma Mason, Janet Blümli
Tel: +43 (0) 1 260 69 2010 or
+43 (0) 1 260 69 2011
Fax: +43 (0) 1 260 69 2012

Emma Mason | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>