Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First pregnancies reported using a new, needle-free device for administering hormones to IVF women

03.07.2002


Fear of needles and the discomfort of daily injections could soon be a thing of the past for women undergoing IVF treatment thanks to a new device which can administer hormones without a needle injection.



Dr Stuart Lavery, a Subspeciality Fellow in Reproductive Medicine and Surgery at the Hammersmith Hospital in London, UK, told the European Society of Human Reproduction and Embryology conference in Vienna today (Wednesday 3 July) that a team at the hospital had achieved the first pregnancies using the needle-free device which is called a J-Tip.

To retrieve eggs from the ovary of a woman undergoing IVF treatment, doctors have to stimulate the ovaries to go into overdrive and produce several follicles (groups of cells) containing the eggs. They do this by injecting hormones into the woman over a period of time before they perform the operation to retrieve the follicles. For women who are "needle-phobic" the regular injections can be a problem.


The J-Tip is a single-use, disposable device, capable of delivering a liquid therapeutic agent under the skin. It is about 10 cms long and it works by using a compressed carbon dioxide gas cartridge to propel the medication, under high pressure, through the skin into the subcutaneous layer below. The high pressure enables the medication itself to pierce the skin, thereby avoiding the use of a needle.

The team led by Mr Geoffrey Trew, a consultant gynaecologist at the Hammersmith, tested the J-Tip on 20 patients between the ages of 20 and 38 years old, who were undergoing IVF treatment, to see how effective it was in prompting controlled ovarian hyperstimulation. They also wanted to test how easy it was to use, how acceptable it was to the patients and whether its use could result in pregnancies.

Nurses used the J-Tip to deliver recombinant follicle stimulating hormone (Puregon NV Organon) to the women once a day for an average of 10 days. Subsequently the researchers were able to retrieve an average of 12 eggs each from 16 of the 20 women. The treatment of one patient was cancelled due to poor response, one was cancelled due to the number of technically incorrect J-Tip injections, and two women asked to withdraw from the study. As a result of successful egg collection, four of the women then became pregnant.

Dr Lavery said: "The results in this small study were reassuringly comparable with conventional techniques in terms of number of eggs collected and pregnancy rates. This is the first time that the J-Tip has been used in reproductive medicine and we can report the first pregnancies achieved using this system. The study shows that the J-Tip is capable of delivering hormones in a new and less invasive way.

"The development of a needle-free injection system is an important target in the improvement of patient convenience in IVF, where the drug treatment phase can require daily injections for several weeks, which for many can be a stressful experience, particularly for those who have a fear of needles. Although nurses administered the J-Tip injections, the ultimate aim is for the patients to be able to do it themselves. Diaries kept by patients during their treatment indicated a high level of patient acceptance of the J-Tip. All the women had undergone conventional IVF cycles previously and their diaries indicate a clear preference for the needle-free approach."


Abstract no: O-203 (Wednesday 10.00hrs CET Hall A) URL: http://conf.eshre.com/PDF/O-203.pdf

Note: A costing on the J-Tip device is still in development.

Further information:
Margaret Willson, information officer
Tel: +44 (0) 1536 772181
Fax: +44 (0) 1536 77219
Mobile: +44 (0) 7973 853 347
Email: m.willson@mwcommunications.org.uk

Emma Mason, information officer
Tel: +44 (0) 1376 563090
Fax: +44 (0) 1376 563272
Mobile: +44 (0) 7711 296 986
Email: wordmason@aol.com

Press Office: (Sunday 30 June – Wednesday 3 July)
Margaret Willson, Emma Mason, Janet Blümli
Tel: +43 (0) 1 260 69 2010 or
+43 (0) 1 260 69 2011
Fax: +43 (0) 1 260 69 2012


Emma Mason | EurekAlert!
Further information:
http://conf.eshre.com/PDF/O-203.pdf

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>