Investigators reporting at the 49th Annual Meeting of the Society of Nuclear Medicine (SNM) have determined that a noninvasive nuclear medicine technique can accurately and safely detect the extent of persistent heart muscle damage after a heart attack. In two studies, researchers reported on the safety and efficacy 201Tl/99mTc Annexin (ApomateTM) SPECT in detecting and localizing myocardial tissue damage and revealing areas of persistent cellular injury. SPECT (single-photon emission computed tomography) is a nuclear medicine procedure that uses the injection of a radiotracer to produce three-dimensional computer-reconstructed images that reveal information about both structure and function.
In one study, Neil Steinmetz, MD, and colleagues from eight medical centers in the U.S. and Canada reported on the use of 201Tl/99mTc Annexin SPECT in 59 patients who had experienced a myocardial infarction (MI) within the previous 96 hours. 81% of these patients showed persistent myocardial tissue injury on imaging. Even in patients who had been successfully revascularized (blood flowing normally to the heart), the 201Tl/99mTc Annexin SPECT revealed areas of persistent cellular damage. In a second study, Raymond Taillefer, MD, and colleagues from the Centre Hospitalier de lUniversité de Montréal (Canada), provided additional evidence that this imaging procedure is effective during the first 4 days after an MI.
Apomate (Theseus Imaging, Boston, MA) is a radiopharmaceutical originally developed for imaging cell death (apoptosis and necrosis) as an early indicator of response to anticancer treatment. The studies reported at the SNM meeting are part of a larger effort to use Apomate and nuclear medicine techniques to determine the extent and location of myocardial cellular injury after an infarction and the response to treatment. Evidence presented at the SNM meeting suggests that Annexin SPECT is safe and effective in detecting persistent areas of damage and diagnosing the extent of past myocardial injury in patients who have experienced MIs. Using this information, physicians may be able to tailor treatment plans and lifestyle changes to the specific needs of each patient Myocardial infarction is the medical term for a heart attack and results when the supply of oxygen is cut off to some portion of the heart muscle. The American Heart Association estimates that more than a million Americans will experience a heart attack in 2002, and more than 300,000 American will die of sudden cardiac arrest.
Karen Lubieniecki | EurekAlert
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
12.12.2017 | Earth Sciences
12.12.2017 | Power and Electrical Engineering
12.12.2017 | Life Sciences