The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
Patients hospitalized with COPD frequently require mechanical ventilation – either invasive or noninvasive – to help them breathe. IMV requires insertion of a rigid tube into the airway which allows oxygen to enter and exit the lungs freely. Invasive methods often involve a significant risk of infection which can occur when bacteria gather around the tube and its fittings. As a result, NIPPV methods are used when possible to minimize infection risks. NIPPV relies on the use of a mask to deliver pressurized air through the mouth and nose.
The two common forms of NIPPV are continuous positive airway pressure (CPAP), which provides a continuous pressurized stream of air, and bilevel positive airway pressure (BPAP), which offers different pressures for inhalation and exhalation. "We performed the first examination of the patterns and outcomes of NIPPV treatment for acute exacerbations of COPD in clinical practice nationwide, using data from an estimated 7,511,267 million hospital admissions in the United States during 1998-2008," said Fernando Holguin, MD, MPH, an assistant professor of medicine in the Pulmonary, Allergy and Critical Care Division at the University of Pittsburgh School of Medicine. "The current study, to the best of our knowledge, is the first to report a dramatic shift towards NIPPV use for treating respiratory failure from acute exacerbations in the United States."
The increase is consistent with results reported by investigators in smaller studies, he said.
For this study, researchers from the University of Pittsburgh, Emory University, the University of Illinois at Chicago and the University of Kentucky reviewed clinical patient data gathered by the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP-NIS) database between 1998 and 2008. The researchers examined changes in the frequency of NIPPV and IMV use from 1998 to 2008, and compared patient demographics, income status, payer type, hospital region and hospital type among patients who initially received NIPPV, IMV or no respiratory support after hospital admission. They also examined in-hospital mortality, length-of-stay and total hospitalization charges, and compared those outcomes among patient groups.
At the completion of the study, they found that although the annual number of hospitalizations for acute exacerbations remained relatively constant during the 10-year period, there was a progressive increase in the use of NIPPV and a progressive decrease in use of IMV; during the entire study period, there was a fourfold increase in the use of NIPPV, which had grown to overtake IMV as the most frequently used form of respiratory support for patients hospitalized with acute exacerbations in the United States.
They also found that despite a steady decline in mortality among most patients studied, patients who used NIPPV and were then transitioned to IMV had significantly higher mortality rates than other patients, and that the mortality rate in these transitioned patients increased during the study period while mortality rates of other groups declined. Patients in this group also experienced the greatest increase in hospital charges and longest hospital length-of-stay.
"The concerning finding in our analysis was the high mortality in the group of patients who, despite initial treatment with NIPPV, required subsequent placement on IMV," said Dr. Holguin, who also serves as the assistant director of the University of Pittsburgh Medical Center's Asthma Institute at the University of Pittsburgh School of Medicine. "It is notable that this finding is contrary to that found in the carefully monitored patient environment of clinical trials, where those transitioned from NIPPV to IMV did not have higher mortality than patients placed on IMV from the beginning."
Dr. Holguin added that the overall trend toward greater use of NIPPV was likely due to several factors, including clinical trials linking NIPPV with a decrease in hospital mortality, increased confidence in using NIPPV and the ability to use NIPPV outside of the intensive care unit.
"These results suggest that healthcare providers should continue to be aggressive with the use of noninvasive ventilation for patients with acute exacerbations, but definitely should intensively monitor sick patients, intervene early in the absence of improvement, and carefully examine if transitioning to IMV is in the interest of a patient with a poor prognosis," he said.
Brian Kell | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
24.05.2017 | Physics and Astronomy
24.05.2017 | Physics and Astronomy
24.05.2017 | Event News