A University of Iowa physiologist has a new technique to measure the stiffness of the aorta, a common risk factor for heart disease. And it can be as simple as measuring the pulse in your finger.
The new procedure developed by Gary Pierce, assistant professor in the Department of Health and Human Physiology, works by placing an instrument called a transducer on the finger or over the brachial artery, located inside the arm just beneath the elbow. The readout, combined with a person’s age and body mass index, lets physicians know whether the aorta has stiffened.
Currently, physicians see whether a patient has a hardened aorta by recording a pulse from the carotid artery, located in the neck, and the femoral artery, which is located in the groin. Taking a pulse from the finger or on the arm is easier to record and nearly as accurate, Pierce says. It also works better with obese patients, whose femoral pulse can be difficult to obtain reliably, he adds.
"The technique is more effective in that it is easy to obtain just one pulse waveform in the finger or the brachial artery, and it's less intrusive than obtaining a femoral waveform in patients," says Pierce, first author on the paper, published in the American Journal of Physiology - Heart and Circulatory Physiology. "It also can be easily obtained in the clinic during routine exams similar to blood pressure tests."
Heart disease is the leading cause of death for both men and women in the United States, killing about 600,000 people every year, according to the federal Centers for Disease Control and Prevention.
One key to a healthy heart is a healthy aorta. A person’s heart has to work harder when the aorta, the large artery that leaves the heart and delivers blood to the body’s tissues, stiffens due to aging and an inactive lifestyle. The harder a person’s heart needs to work, the higher risk he or she has for developing high blood pressure, stroke and a heart attack.
Since people can live for years without any knowledge of existing cardiovascular problems, this new measurement tool is especially important. It can provide useful diagnostic information for middle-aged and older patients, who are most susceptible to having hardened arteries that can lead to heart disease.
Regular assessments of the aorta may help reduce those risks. Pierce’s instrument measures notes the speed, called aortic pulse wave velocity, at which the pulse moves between two points. The UI team validated the new instrument’s performance against the carotid-femoral-artery pulse wave velocity tests, considered the gold standard for determining aortic stiffness.
“Finding simple noninvasive methods to measure aortic pulse wave velocity in the clinic may help physicians to better inform middle-aged and older adults about their level of cardiovascular risk,” Pierce says, noting that past studies have shown that regular exercise protects the aorta from hardening in those age groups.
The paper’s corresponding author is Harald Stauss, associate professor in health and human physiology. Other authors from the UI include Darren Casey, Jess Fiedorowicz, and DeMaris Wilson. Douglas Seals from the University of Colorado-Boulder and Timothy Curry and Jill Barnes from the Mayo Clinic in Rochester, Minn. also contributed to the paper.
The National Institutes of Health (grant award numbers T32 383 AG000279, HL105467, AG013038, F32 AG038067, K23 384, DK082424, UL1RR024979 and UL1RR025780), the American Heart Association and the UI funded the study.
ContactsGary Pierce, Health and Human Physiology, 319-335-9487
Richard Lewis | EurekAlert!
Researchers show p300 protein may suppress leukemia in MDS patients
28.03.2017 | University of Miami Miller School of Medicine
When writing interferes with hearing
28.03.2017 | Université de Genève
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Physics and Astronomy
28.03.2017 | Health and Medicine
28.03.2017 | Life Sciences