Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Depression may increase risk of Alzheimer's disease in people with memory problems

16.06.2009
People with memory problems who are depressed are more likely to develop Alzheimer's disease compared to people who are not depressed, according to a study published in the June 16, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.

However, the research also shows that the popular Alzheimer's drug donepezil may delay the progression to Alzheimer's disease for depressed people with mild cognitive impairment (MCI) or memory problems.

MCI is described as the period in-between normal aging and Alzheimer's disease. A person with MCI experiences memory problems that are greater than expected with normal aging but does not show other symptoms of Alzheimer's disease, such as difficulties in completing everyday activities.

For the study, researchers followed 756 people with MCI who were between the ages of 55 and 91 for three years. Of those, 208 were diagnosed with depression using a test that measures the severity and intensity of a person's depressive symptoms. For every one point increase on the test, a participant's risk of developing Alzheimer's disease went up by three percent.

"Our longer term findings add to the body of evidence that suggests depression is a major risk factor for Alzheimer's disease," said study author Po H. Lu, PsyD, assistant professor of neurology with the David Geffen School of Medicine at UCLA in Los Angeles. "Since the drug donepezil has been shown to improve the behavioral symptoms of Alzheimer's disease, our study also tested whether the drug would delay the progression to Alzheimer's disease in people with memory problems."

Participants were given either vitamin E, donepezil or a placebo pill. The study found that at 1.7 years, among depressed people with mild cognitive impairment, 11 percent of those taking donepezil developed Alzheimer’s disease compared to 25 percent of those who took vitamin E or placebo. At 2.2 years, 14 percent of those taking donepezil developed Alzheimer's compared to 29 percent of those who took vitamin E or placebo. Donepezil had little effect in the group of people who were not depressed.

"If we can delay the progression of this disease for even two years, it could significantly improve the quality of life for many people dealing with memory loss," said Lu.

Donepezil is not approved for use in mild cognitive impairment by the FDA. It is indicated for mild to moderate and severe Alzheimer's disease.

The study was supported by the National Institute on Aging, the Alzheimer's Association, the Alzheimer's Disease Cooperative Study grant, the Alzheimer's Disease Research Center, Jim Easton and the Sidell Kagan Foundation.

The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as stroke, Alzheimer's disease, epilepsy, Parkinson's disease, and multiple sclerosis.

Rachel Seroka | EurekAlert!
Further information:
http://www.aan.com
http://www.TheBrainMatters.org

Further reports about: Academy Depression Disease MCI Neurology memory problems mild cognitive impairment

More articles from Health and Medicine:

nachricht Vanishing capillaries
23.03.2017 | Technische Universität München

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>