Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Liver therapy with ultrasound

27.03.2014

Fraunhofer MEVIS coordinates EU-project for further development of an innovative, conservative therapy

Tumor removal without a scalpel or x-rays is now possible due to a special type of ultrasound. Strong, concentrated ultrasonic waves are directed at the patient’s body in such a way that they heat and kill individual cancer cells.


Illustration of numerically simulated high-intensity focused ultrasound therapy.

A new EU-project wants to transfer this emerging, non-invasive therapy to moving organs, specifically the liver. The Fraunhofer MEVIS Institute for Medical Image Computing Bremen is coordinating “TRANS-FUSIMO”.

At present, the “focused ultrasound (FUS) therapy” is approved for only two diseases – prostate cancer and selected uterine myoma. These can be treated without surgery or exposure to radiation, though liver tumors cannot due to the motion of the organ caused by respiratory movement.

This movement complicates pointing the concentrated ultrasonic wave on the tumor, as the emitted heat spreads over a larger area, inhibiting its desired effect. There is also a higher risk of damaging the surrounding tissue, not achieving the desired therapy outcome. In this case, recurrences of the tumor may occur.

Over the past three years, the scope of the EU funded project, FUSIMO (“Patient Specific Modelling and Simulation of Focused Ultrasound In Moving Organs”, www.fusimo.eu), has laid the foundation for transferring FUS to moving organs.

The first step is to obtain 3D images from magnetic resonance tomography (MRT) that show the inside of the patient’s abdomen and simultaneously register the respiratory movements. Based on this data, experts can perform computer simulations of ultrasound treatment on the liver.

In the simulation, our software computes how the liver moves under respiration and thus can direct the virtual ultrasonic waves in such a way that they follow the movement of the liver and remain focused on the tumor. “In the future, such simulations can enable physicians to plan complex ultrasound interventions individual to the patient and in great detail”, says MEVIS-researcher Jan Strehlow.

“This is especially important in moving organs and can be decisive for indication whether this method of therapy is a viable option for a patient.” Furthermore, computer simulations may help shorten the duration of the ultrasound treatment.

The EU-Project, TRANS-FUSIMO, enables experts to take the next step: they strive to transfer virtual principles into real world applications and develop a system for patient treatment in the clinic. For this, a MR-scanner with a strong ultrasonic transmitter and a regular ultrasonic device are to be combined.

The latter registers the movement of the liver during respiration, in real time, while the patient is in the MR-scanner. Based on this data, the software calculates the path that the strong ultrasonic wave should take in order to stay focused on the tumor in spite of respiratory movement. During the treatment, the MR-scanner measures the distribution of temperature in the abdominal region, which allows physicians to precisely control the ultrasonic rays to target the tumor as desired.

Fraunhofer MEVIS is coordinating this EU-project and developing real-time control of all hardware systems. “Our aim is a product-capable system, for which we seek clinical approval”, says MEVIS-researcher Sabrina Haase. Over the next two years, the technology is to be tested on patients under general anesthesia; their breathing will be artificially halted, so that there is no liver movement for a short period of time. In 2018, the first patients without anesthesia are to be treated while breathing naturally. If these studies yield positive results, the new procedure may be approved.

The Fraunhofer Institute for Medical Image Computing MEVIS
Embedded in a worldwide network of clinical and academic partners, Fraunhofer MEVIS develops real-world software solutions for image-supported early detection, diagnosis, and therapy. Strong focus is placed on cancer as well as diseases of the circulatory system, brain, breast, liver, and lung. The goal is to detect diseases earlier and more reliably, tailor treatments to each individual, and make therapeutic success more measurable. In addition, the institute develops software systems for industrial partners to undertake image-based studies to determine the effectiveness of medicine and contrast agents. To reach its goals, Fraunhofer MEVIS works closely with medical technology and pharmaceutical companies, providing solutions for the entire chain of development from applied research to certified medical products. http://www.mevis.fraunhofer.de/en

TRANS-FUSIMO
TRANS-FUSIMO stands for “Clinical Translation of Patient-Specific Planning and Conducting of FUS Treatment in Moving Organs”. The EU-project was launched in January 2014 and will run for a period of five years with approximately 5.6 mil Euros in funding. Ten institutes from seven countries, including clinics, universities and four medical engineering institutes are participating. The Fraunhofer MEVIS Institute for Medical Image Computing Bremen is coordinating TRANS-FUSIMO.
http://www.trans-fusimo.eu

Weitere Informationen:

http://www.mevis.fraunhofer.de/en/news/press-release/article/liver-therapy-with-...

Bianka Hofmann | Fraunhofer MEVIS

Further reports about: Computing Strong anesthesia diseases liver movement organs therapy waves

More articles from Medical Engineering:

nachricht MRI technique differentiates benign breast lesions from malignancies
20.02.2018 | Radiological Society of North America

nachricht True to type: From human biopsy to complex gut physiology on a chip
14.02.2018 | Wyss Institute for Biologically Inspired Engineering at Harvard

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Researchers invent tiny, light-powered wires to modulate brain's electrical signals

21.02.2018 | Life Sciences

The “Holy Grail” of peptide chemistry: Making peptide active agents available orally

21.02.2018 | Life Sciences

Atomic structure of ultrasound material not what anyone expected

21.02.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>