Dr. Ning Yuan, Beijing Jishuitan Hospital, China and his colleagues, developed a novel neural stem cell scaffold that has two layers: the inner loose layer and the outer compact layer.
The loose layer was infiltrated with a large amount of neural stem cells before it was transplanted in vivo. Thus a plenty of neural stem cells can be provided at the target spinal cord site.
Through transmission electron microscope, neural stem cells attached to the double-layer collagen membrane with unequal pore sizes and there was no structural change in the double-layer collagen membrane.
Credit: Neural Regeneration Research
The loose layer was adhered to the injured side and the compact layer was placed against the lateral side. The compact layer has very small holes, so it can prevent ingrowth of adjacent scar tissue.
It can also prevent the loss of inner neural stem cells and the neural growth factors secreted by the differentiated neural stem cells.
Thus a good microenvironment forms to help spinal cord injury repair. Yuan Ning and colleagues found that transplantation of neural stem cells in a double-layer collagen membrane with unequal pore sizes is an effective therapeutic strategy to repair an injured spinal cord in rats.
Related results were published in Neural Regeneration Research (Vol. 9, No. 10, 2014).
Article: " Neural stem cell transplantation in a double-layer collagen membrane with unequal pore sizes for spinal cord injury repair," by Ning Yuan1, Wei Tian1, Lei Sun2, Runying Yuan2, Jianfeng Tao2, Dafu Chen2 (1 Department of Spine, Beijing Jishuitan Hospital, Beijing, China; 2 Beijing Institute of Orthopedics and Traumatology, Beijing, China) Yuan N, Tian W, Sun L, Yuan RY, Tao JF, Chen DF. Neural stem cell transplantation in a double-layer collagen membrane with unequal pore sizes for spinal cord injury repair. Neural Regen Res. 2014;9(10):1014-1019.
Meng Zhao | Eurek Alert!
Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg
Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Life Sciences
18.01.2018 | Life Sciences
18.01.2018 | Earth Sciences