Dr. Ning Yuan, Beijing Jishuitan Hospital, China and his colleagues, developed a novel neural stem cell scaffold that has two layers: the inner loose layer and the outer compact layer.
The loose layer was infiltrated with a large amount of neural stem cells before it was transplanted in vivo. Thus a plenty of neural stem cells can be provided at the target spinal cord site.
Through transmission electron microscope, neural stem cells attached to the double-layer collagen membrane with unequal pore sizes and there was no structural change in the double-layer collagen membrane.
Credit: Neural Regeneration Research
The loose layer was adhered to the injured side and the compact layer was placed against the lateral side. The compact layer has very small holes, so it can prevent ingrowth of adjacent scar tissue.
It can also prevent the loss of inner neural stem cells and the neural growth factors secreted by the differentiated neural stem cells.
Thus a good microenvironment forms to help spinal cord injury repair. Yuan Ning and colleagues found that transplantation of neural stem cells in a double-layer collagen membrane with unequal pore sizes is an effective therapeutic strategy to repair an injured spinal cord in rats.
Related results were published in Neural Regeneration Research (Vol. 9, No. 10, 2014).
Article: " Neural stem cell transplantation in a double-layer collagen membrane with unequal pore sizes for spinal cord injury repair," by Ning Yuan1, Wei Tian1, Lei Sun2, Runying Yuan2, Jianfeng Tao2, Dafu Chen2 (1 Department of Spine, Beijing Jishuitan Hospital, Beijing, China; 2 Beijing Institute of Orthopedics and Traumatology, Beijing, China) Yuan N, Tian W, Sun L, Yuan RY, Tao JF, Chen DF. Neural stem cell transplantation in a double-layer collagen membrane with unequal pore sizes for spinal cord injury repair. Neural Regen Res. 2014;9(10):1014-1019.
Meng Zhao | Eurek Alert!
Great apes communicate cooperatively
25.05.2016 | Max-Planck-Institut für Ornithologie
Rice study decodes genetic circuitry for bacterial spore formation
24.05.2016 | Rice University
Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.
The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...
In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.
In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...
Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices
Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.
When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene
In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...
The trend-forward world of display technology relies on innovative materials and novel approaches to steadily advance the visual experience, for example through higher pixel densities, better contrast, larger formats or user-friendler design. Fraunhofer ISC’s newly developed materials for optics and electronics now broaden the application potential of next generation displays. Learn about lower cost-effective wet-chemical printing procedures and the new materials at the Fraunhofer ISC booth # 1021 in North Hall D during the SID International Symposium on Information Display held from 22 to 27 May 2016 at San Francisco’s Moscone Center.
24.05.2016 | Event News
20.05.2016 | Event News
19.05.2016 | Event News
25.05.2016 | Trade Fair News
25.05.2016 | Life Sciences
25.05.2016 | Power and Electrical Engineering